人乳头瘤病毒相关头颈肿瘤的中文文献研究现状分析

发布时间：2018-07-26 07:41

【摘要】：目的基于目前国内人乳头瘤病毒(HPV)相关的头颈肿瘤的文献,结合国外文献研究,分析目前我国在此领域的研究现状。方法计算机检索四川大学图书馆电子期刊数据库,包括中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)和万方期刊全文数据库,筛选并提取数据,分析国内与HPV相关的头颈肿瘤研究的基本特征、HPV总检出率以及不同临床病理指标对HPV感染的影响。结果国内头颈肿瘤患者中,HPV总检出率为34.05%。在分析不同临床病理指标对口腔鳞癌患者HPV感染的影响时,不吸烟组、不饮酒组的HPV感染率高于吸烟组(P=0.002)、饮酒组(P0.005);N2~N3期的HPV检出率高于N0~N1期(P=0.027)。结论 HPV相关头颈肿瘤的中文文献多数以临床研究为主,未来应继续研究致病的分子病理机制以及预后的分子信号通路,更多关注具有前瞻视角的治疗型HPV疫苗和分子靶向的研究。
[Abstract]:Objective to analyze the current situation of human papillomavirus (HPV) (HPV) related head and neck tumors in China. Methods the electronic periodical database of Sichuan University Library was searched by computer, including the Chinese Biomedical Literature Database (CBM),) and the full text Database of Wanfang Journals (VIP), and the data were screened and extracted. To analyze the basic characteristics of head and neck tumors related to HPV in China, the total detection rate of HPV and the influence of different clinicopathological indexes on HPV infection were analyzed. Results the total detection rate of HPV in head and neck tumor patients was 34.05. In order to analyze the effect of different clinicopathological indexes on HPV infection in oral squamous cell carcinoma patients, the HPV infection rate in non-smoking group and non-drinking group was higher than that in smoking group (P0.002), and the detection rate of HPV in drinking group (P0.005) was higher than that in N0~N1 stage (P0.027). Conclusion most of the Chinese literature on HPV related head and neck tumors are mainly clinical studies. We should continue to study the molecular pathological mechanism and the molecular signal pathway of prognosis in the future. More attention has been paid to therapeutic HPV vaccines and molecular targeting with prospective perspectives.
【作者单位】：口腔疾病研究国家重点实验室国家口腔疾病临床研究中心四川大学华西口腔医院口腔颌面外科;
【基金】：国家自然科学基金国际(地区)合作交流项目NSFC-NIH(中美)国际合作项目(81361120399)~~
【分类号】：G353.1;R739.91

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