th细胞因子_淋巴细胞因子_PNAS：平息致命的免疫风暴

  本文关键词：细胞因子风暴，由笔耕文化传播整理发布。

细胞因子风暴是指免疫细胞及其活性产物（细胞因子）过量生产的现象。在流感病毒感染时，细胞因子风暴会导致大量活化的免疫细胞涌入肺部，而这种情况往往会提高患者的死亡率。

生物通编辑：叶予

生物通推荐原文摘要：

Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection

During pathogenic influenza virus infection, robust cytokine production (cytokine storm), excessive inflammatory infiltrates, and virus-induced tissue destruction all contribute to morbidity and mortality. Earlier we reported that modulation of sphingosine-1-phosphate-1 receptor (S1P1R) signaling provided a chemically tractable approach for the effective blunting of cytokine storm, leading to the improvement of clinical and survival outcomes. Here, we show that S1P1R agonist treatment suppresses global cytokine amplification. Importantly, S1P1R agonist treatment was able to blunt cytokine/chemokine production and innate immune cell recruitment in the lung independently of endosomal and cytosolic innate sensing pathways. S1P1R signaling suppression of cytokine amplification was independent of multiple innate signaling adaptor pathways for myeloid differentiation primary response gene 88 (MyD88) and IFN-β promoter stimulator-1 signaling, indicating a common pathway inhibition of cytokine storm. We identify the MyD88 adaptor molecule as responsible for the majority of cytokine amplification observed following influenza virus challenge.

  本文关键词：细胞因子风暴，由笔耕文化传播整理发布。