急支糖浆或抗生素治疗单纯急性气管-支气管炎的随机对照临床研究

发布时间：2017-12-27 23:35

本文关键词：急支糖浆或抗生素治疗单纯急性气管-支气管炎的随机对照临床研究　出处：《中药药理与临床》2015年01期 　论文类型：期刊论文

【摘要】：目的:评价口服急支糖浆或抗生素治疗单纯急性气管-支气管炎的疗效。方法:采用随机对照方法,将180例患者随机分为急支糖浆90ml组、60ml组和阿莫西林组。急支糖浆90ml组,一次30ml,一日3次;急支糖浆60ml组,一次20ml,一日3次;阿莫西林组,一次0.5g,一日3次。疗程2周。主要疗效指标为频繁咳嗽天数。结果:频繁咳嗽天数急支糖浆90ml组(中位数8天,95%可信区间7.06~8.94天;均数8.71天,95%可信区间7.81~9.62天)和60ml组(中位数9天,95%可信区间8.01~9.88天;均数9.68天,95%可信区间8.78~10.56天)低于阿莫西林组(中位数11天,95%可信区间8.67~13.33天;均数10.45天,95%可信区间9.57~11.34天),3组比较差异有统计学意义(P0.05);疾病痊愈率急支糖浆90ml组(91.7%)和60ml组(83.3%)高于阿莫西林组(73.3%),3组比较差异有统计学意义(P0.05)。不良反应发生率急支糖浆组(3.3%)少于阿莫西林组(11.7%)。结论:急支糖浆治疗单纯急性气管-支气管炎的疗效优于阿莫西林胶囊,不良反应发生率低。
[Abstract]:Objective: To evaluate the efficacy of oral acute bronchitis or antibiotics in the treatment of simple acute tracheal bronchitis. Methods: 180 patients were randomly divided into 90ml group, 60ml group and amoxicillin group by random control method. 90ml group of acute branch syrup, one time 30ml, 3 times a day, 60ml group of acute syrup, one time 20ml, 3 times a day, amoxicillin, one 0.5g, 3 times a day. The course of treatment was 2 weeks. The main therapeutic index was the number of frequent coughing days. Results: the frequent cough Jizhi syrup group 90ml days (median 8 days, 95% confidence interval 7.06~8.94 days; average 8.71 days, 95% confidence interval 7.81~9.62 days) and 60ml group (median 9 days, 95% confidence interval 8.01~9.88 days; average 9.68 days, 95% confidence interval 8.78~10.56 days) than amoxicillin group (median 11 days and the 95% confidence interval of 8.67~13.33 days; average 10.45 days, 95% confidence interval 9.57~11.34 days), there was significant difference between 3 groups (P0.05); disease cure rate of acute bronchitis syrup 90ml group (91.7%) and 60ml group (83.3%) was higher than that of amoxicillin group (73.3%), there was significant difference between 3 groups (P0.05). The incidence of ADR in acute syrup group (3.3%) was less than amoxicillin (11.7%). Conclusion: the curative effect of acute bronchitis with acute bronchitis is better than that of Amoxicillin Capsules, and the incidence of adverse reaction is low.
【作者单位】：张家口市第二医院;武警石家庄指挥学院门诊部;河北以岭医院;
【分类号】：R562.2
【正文快照】： 急性气管-支气管炎是一种危害人民健康的常见病和多发病,临床症状主要为咳嗽和咳痰[1]。在门诊患者中急性气管-支气管炎病例是肺炎的20倍,支气管哮喘的10倍[2]。病人大多是因持久和严重的咳嗽影响到正常的工作、生活而去医院进行治疗。咳嗽、咳痰可延续2~3周或更长的时间。该

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