痰菌阴性肺结核患者血清白细胞介素-6、白细胞介素-10、白细胞介素-23、骨桥蛋白水平的动态变化及临床意义

发布时间：2017-12-31 06:07

本文关键词：痰菌阴性肺结核患者血清白细胞介素-6、白细胞介素-10、白细胞介素-23、骨桥蛋白水平的动态变化及临床意义　出处：《中国感染与化疗杂志》2016年03期 　论文类型：期刊论文

【摘要】：目的探讨痰菌阴性(菌阴)肺结核患者治疗前后血清白细胞介素(IL)-6、IL-10、IL-23、骨桥蛋白(OPN)动态变化及其临床意义。方法选择初治的菌阴肺结核患者43例,正常对照组40例,应用双抗体夹心酶联免疫吸附法(ELISA)测定正常对照组和菌阴肺结核组治疗前、治疗2个月后、治疗4个月后、治疗6个月后血清IL-6、IL-10、IL-23、OPN的水平。结果菌阴肺结核组治疗前血清IL-6、IL-10、IL-23、OPN水平均明显高于正常对照组,差异有统计学意义(P0.05)。经过治疗2个月后患者血清IL-6、IL-10、IL-23、OPN水平开始降低,与治疗前比较差异有统计学意义(P0.05)。治疗4个月后血清IL-10和OPN接近正常水平,与对照组比较差异无统计学意义(P0.05);IL-6、IL-23水平进行性降低,治疗6个月后接近正常水平,与对照组比较差异无统计学意义(P0.05)。结论菌阴肺结核治疗过程中动态观察IL-6、IL-10、IL-23、OPN水平,可作为评估病情转归及抗结核药物治疗有效性的敏感指标。
[Abstract]:Objective to investigate the serum interleukin (IL) -6 (IL-10) IL-23 in sputum negative pulmonary tuberculosis (TB) patients before and after treatment. Dynamic changes of OPN (osteopontin) and its clinical significance. Methods 43 newly treated pulmonary tuberculosis patients and 40 normal controls were selected. The serum IL-6 was measured by double antibody sandwich enzyme linked immunosorbent assay (Elisa) before treatment, 2 months after treatment, 4 months after treatment and 6 months after treatment in normal control group and pulmonary tuberculosis group. Results the serum levels of IL-6, IL-10 and IL-23 OPN in patients with pulmonary tuberculosis were significantly higher than those in normal controls before treatment. The difference was statistically significant (P 0.05). After 2 months of treatment, the serum level of IL-6, IL-10 and IL-23 OPN began to decrease. After 4 months of treatment, the levels of serum IL-10 and OPN were close to the normal level, but there was no significant difference compared with the control group (P 0.05). The levels of IL-6 and IL-23 decreased progressively, and were close to the normal level after 6 months of treatment. Conclusion the level of IL-6, IL-10, IL-23 and OPN was observed dynamically during the treatment of pulmonary tuberculosis of bacterial negative. It can be used as a sensitive index to evaluate the outcome of the disease and the efficacy of anti-tuberculosis drugs.
【作者单位】：胜利油田中心医院呼吸内科;
【分类号】：R521
【正文快照】： 结核免疫主要是由T淋巴细胞所介导的细胞免疫反应,多种细胞因子参与了结核病的免疫应答及免疫发病过程,可以说结核病是一种免疫紊乱性疾病[1]。患者体内细胞因子的水平一定程度上能反映免疫状态,其变化趋势可能对判断患者病情发展趋势及药物疗效有重要指导意义。为了揭示肺结

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