IL-33在呼吸系统疾病中的作用机制与意义

发布时间：2018-01-02 04:05

本文关键词：IL-33在呼吸系统疾病中的作用机制与意义　出处：《现代免疫学》2015年05期 　论文类型：期刊论文

【摘要】：呼吸系统疾病发病率和致死率高,是严重危害患者生命和生活质量的主要疾病,其中以肺癌、肺结核、支气管哮喘和慢性阻塞性肺疾病最为常见,且这类疾病的发生和发展与慢性炎症有关。IL-33是IL-1家族新成员,具有炎症因子的功能。研究表明,IL-33可通过与其受体ST2(suppression of tumorigenicity,ST2)结合促进免疫细胞分泌IL-5和IFN-γ等细胞因子,参与体内多种疾病的免疫应答过程,与肺癌、肺结核、支气管哮喘和慢性阻塞性肺病的发生和发展密切相关。研究IL-33在呼吸道疾病发生和发展中的机制有望给患者带来新的诊疗策略。
[Abstract]:The incidence of respiratory diseases and high mortality, is the main disease of serious harm to the life and quality of life, including lung cancer, tuberculosis, bronchial asthma and chronic obstructive pulmonary disease is the most common, and the occurrence and development of chronic inflammation and the disease related to.IL-33 is a new member of the IL-1 family, with inflammatory factors function. The results show that IL-33 can through its receptor ST2 (suppression of tumorigenicity, ST2) combined with promoting immune cells secreting IL-5 and IFN- gamma and other cytokines, immune response, are involved in various diseases and lung cancer, tuberculosis, closely related to the occurrence and development of bronchial asthma and chronic obstructive pulmonary disease. The mechanism of IL-33 in respiratory disease occurrence and development is expected to bring new treatment strategies for patients.

【作者单位】：苏州大学附属第三医院呼吸科;
【基金】：国家自然科学基金项目(81171653);国家自然科学基金海外及港澳学者合作研究基金项目(31428005) 江苏省条件建设与民生科技专项资金项目(BL2014034)
【分类号】：R56
【正文快照】： IL-33是属于IL-1家族的一种细胞因子,其基因在皮肤、肺组织、胃肠道和脑组织中高表达。IL-33主要组成性表达于成纤维细胞、上皮细胞和内皮细胞,其表达受机体损伤或感染后释放的炎症因子调控。IL-33在自身免疫性疾病、变态反应以及心血管肺部疾病中起重要调节作用。近年研究表

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