辛伐他汀对慢性阻塞性肺病患者血浆脑利钠肽水平及疗效的影响

发布时间：2018-01-04 04:00

本文关键词：辛伐他汀对慢性阻塞性肺病患者血浆脑利钠肽水平及疗效的影响　出处：《中国老年学杂志》2015年22期 　论文类型：期刊论文

【摘要】：目的观察辛伐他汀对慢性阻塞性肺病(COPD)患者血浆脑利钠肽(BNP)的影响和疗效。方法将104例COPD患者随机分为对照组和治疗组各52例。均接受常规治疗,治疗组在对照组基础上加用辛伐他汀20 mg晚间服1次,两组疗程均为6个月。采用双抗体免疫夹心层析法测定血清BNP含量。采用肺功能仪分别测定COPD患者肺功能指标,并对所有患者进行治疗前和治疗后的呼吸困难评分。对比两组治疗前、治疗后6个月血浆中BNP水平、肺功能指标和呼吸困难评分指标。结果治疗组治疗6个月后的BNP水平显著低于治疗前和同期对照组(P0.05),第1秒用力呼气容积占预计值百分比(FEV1%)和FEV1/用力肺活量(FVC)肺功能指标较治疗前显著改善(P0.05),治疗组的呼吸困难量表(MRC)和基础呼吸困难指数(BDI)评分与治疗前相比差异显著,且BDI评分与对照组相比差异显著(P0.05)。结论在常规治疗基础上应用辛伐他汀能够显著改善COPD患者肺功能和呼吸困难评分,显著降低血浆BNP水平,缓解心脏负荷,稳定COPD病变。
[Abstract]:Objective to observe the effect of simvastatin on plasma brain natriuretic peptide (BNP) in patients with chronic obstructive pulmonary disease (COPD). Methods 104 patients with COPD were randomly divided into control group (n = 52) and treatment group (n = 52). The treatment group was treated with simvastatin 20mg once a night in addition to the control group. The two groups were treated for 6 months. Serum BNP levels were measured by double antibody immunosandwich chromatography and pulmonary function indexes were measured by pulmonary function analyzer. All patients were assessed for dyspnea before and after treatment. Plasma BNP levels were compared between the two groups before and 6 months after treatment. Results the level of BNP in the treatment group after 6 months was significantly lower than that in the control group and before treatment (P 0.05). At 1 seconds forced expiratory volume as a percentage of predicted value (FEV1) and FEV1 / forced vital capacity (FVC) pulmonary function were significantly improved compared with those before treatment (P 0.05). The scores of dyspnea scale (MRC) and basic dyspnea index (BDI) in the treatment group were significantly different from those before treatment. The BDI score was significantly different from that of the control group (P 0.05). Conclusion Simvastatin can significantly improve pulmonary function and dyspnea score in patients with COPD on the basis of routine treatment. Plasma BNP level was significantly decreased, cardiac load was alleviated and COPD lesion was stabilized.
【作者单位】：延边大学附属医院;
【分类号】：R563.9
【正文快照】： 慢性阻塞性肺病(COPD)是中老年患者中常见的一种肺部疾病,主要病理特征是气道炎症加重〔1,2〕,存在持续的气流受限。药物仍是目前治疗COPD的主要手段。脑利钠肽(BNP)是心力衰竭、缺血性心脏病等的敏感指标〔3〕。COPD患者由于气流阻塞引起肺动脉压力增大同时伴有的血液高凝和

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