肿瘤标志物与特发性肺间质纤维化相关性的临床研究

发布时间：2018-01-07 03:04

本文关键词：肿瘤标志物与特发性肺间质纤维化相关性的临床研究　出处：《中国现代医学杂志》2016年08期 　论文类型：期刊论文

【摘要】：目的探讨肿瘤标志物与特发性肺间质纤维化(IPF)之间的关系及其临床意义,以指导IPF早期临床诊断。方法回顾性对比分析2012年1月-2015年9月于武警总医院住院的IPF患者40例,肺癌患者50例,健康体检者40例,收集3组患者的血清骨胶素(CYFRA211)、烯醇化酶(NSE)、鳞状上皮细胞抗原(SCC)、癌胚抗原(CEA)、抗原125(CA125)、抗原72-4(CA72-4)等肿瘤标志物。结果 IPF患者CYFRA211、NSE、SCC、CEA及CA125水平均显著高于健康对照组(P0.05),而CA72-4水平相当(P0.05)。与肺癌患者比较,IPF患者的血清CA125水平显著升高(P0.05),NSE水平显著降低(P0.05),而其他肿瘤标志物在两组间差异无统计学意义(P0.05)。IPF患者血清SCC、NSE的阳性率与肺癌组差异有统计学意义(P0.05)。在与肺癌的分型比较中,IPF组血清CA125水平高于鳞癌组(P0.05),SCC水平/阳性率显著高于腺癌组和小细胞肺癌组(P0.05),血清NSE水平/阳性率均显著低于3个肺癌亚组(P0.05);其他肿瘤标志物与3个肺癌亚组之间差异无统计学意义(P0.05)。结论 IPF患者血清CYFRA211、NSE、SCC、CEA、CA125明显升高。IPF患者血清CA125、SCC可作为IPF的早期诊断指标,而血清NSE水平可作为区分IPF与早期肺癌的一项预测指标。
[Abstract]:Objective to investigate the tumor markers and idiopathic pulmonary fibrosis (IPF) between the relationship and clinical significance, to guide the clinical diagnosis of early IPF. Methods 40 patients with IPF analysis in the Armed Police General Hospital January 2012 -2015 year in September compared with 50 cases of lung cancer patients and 40 healthy subjects, serum bone collection 3 groups of patients with hormone (CYFRA211), enolase (NSE), squamous cell antigen (SCC), carcinoembryonic antigen (CEA), 125 (CA125) antigen, 72-4 antigen (CA72-4) and other tumor markers. Results IPF patients with CYFRA211, NSE, SCC, CEA and CA125 levels were significantly higher than that of healthy the control group (P0.05), and CA72-4 level (P0.05). Compared with the patients with lung cancer, the serum CA125 level in patients with IPF increased significantly (P0.05), the level of NSE was significantly decreased (P0.05), and other tumor markers in the two groups had no significant difference (P0.05) of serum.IPF in patients with SCC, the positive rate of NSE and lung There are significant differences in cancer group (P0.05). In comparison with type of lung cancer in IPF group, the serum CA125 level was higher in squamous cell carcinoma group (P0.05), the level of SCC / positive rate was significantly higher than that of adenocarcinoma and small cell lung cancer group (P0.05), serum NSE levels were significantly lower than the positive rate of 3 lung cancer subgroup (P0.05); other differences between tumor markers and 3 lung cancer group had no statistical significance (P0.05). Conclusion the serum IPF in patients with CYFRA211, NSE, SCC, CEA, CA125 significantly increased serum.IPF in patients with CA125, SCC can be used as indicators of early diagnosis of IPF, and the level of serum NSE can be used as a predictive index to distinguish IPF and lung cancer.

【作者单位】：辽宁医学院武警总医院研究生培养基地;武警总医院呼吸科;
【分类号】：R563.9
【正文快照】： 特发性肺间质纤维化(idiopathic pulmonary fi-brosis,IPF)是一种不明原因的进行性致纤维化的间质性肺炎,其组织病理学和放射学表现为普通型间质性肺炎。IPF好发于老年人,发病率约为5/10万,中位生存期为2~3年[1]。目前IPF早期诊断较难,临床疗效不佳,预后较差。IPF的发病率呈上

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