2011-2013年患者呼吸道感染铜绿假单胞菌耐药监测分析

发布时间：2018-01-09 22:35

本文关键词：2011-2013年患者呼吸道感染铜绿假单胞菌耐药监测分析　出处：《中华医院感染学杂志》2015年17期 　论文类型：期刊论文

【摘要】：目的了解大庆地区患者呼吸道感染铜绿假单胞菌对临床常用抗菌药物的耐药性,为临床合理用药提供依据。方法比较2011-2013年呼吸道感染患者分离的1 623株铜绿假单胞菌对临床常用抗菌药物耐药性,使用法国生物梅里埃公司VITEK-2全自动细菌鉴定及药敏分析仪进行菌种鉴定,药敏试验采用手工测定法。结果2011年共分离铜绿假单胞菌496株,铜绿假单胞菌对阿米卡星敏感性最高,敏感率为78.48%,其次为美罗培南,敏感率为77.61%;2012年分离出铜绿假单胞菌496株,铜绿假单胞菌对阿米卡星敏感性仍最高,敏感率为92.03%,其次为妥布霉素,敏感率为91.58%;2013年分离出铜绿假单胞菌631株,铜绿假单胞菌对阿米卡星敏感性仍最高,敏感率为86.42%,其次为环丙沙星,敏感率为76.72%。结论铜绿假单胞菌对常用抗菌药物较敏感,传统敏感药物亚胺培南、头孢吡肟及头孢他啶敏感率呈逐年下降趋势,但仍保持约60.00%的敏感性,而阿米卡星及环丙沙星仍保持较高敏感性,可供临床选择。
[Abstract]:Objective to investigate patients with respiratory tract infection in Daqing area of Pseudomonas aeruginosa to commonly used antimicrobial agents, provide the basis for clinical rational drug use. Methods isolated from patients with 2011-2013 to compare the respiratory tract infection of 1623 strains of Pseudomonas aeruginosa to antibiotics resistance bacteria identification using bio Merieux VITEK-2 automatic bacteria identification and drug sensitivity analyzer, manual method was adopted to determine the drug sensitivity test. The results of 2011 were isolated 496 strains of Pseudomonas aeruginosa, Pseudomonas aeruginosa to Amikacin the highest sensitivity, the sensitivity rate was 78.48%, followed by meropenem, the sensitivity rate was 77.61%; in 2012 the isolated 496 strains of Pseudomonas aeruginosa, Pseudomonas aeruginosa is the highest sensitivity to Amikacin. The sensitivity rate was 92.03%, followed by tobramycin, the sensitivity rate was 91.58%; in 2013 the isolated 631 strains of Pseudomonas aeruginosa, Pseudomonas aeruginosa Cellular sensitivity to Amikacin is the highest, the sensitivity rate was 86.42%, followed by ciprofloxacin, the sensitivity rate was 76.72%. conclusion Pseudomonas aeruginosa is sensitive to commonly used antimicrobial drugs, traditional drug sensitive to imipenem, cefepime and ceftazidime sensitive rate decreased year by year, but still maintain a sensitivity of approximately 60%, while Amikacin and ciprofloxacin still maintain higher sensitivity for clinical choice.

【作者单位】：大庆油田总医院;大庆市第一医院呼吸科;
【基金】：黑龙江科技厅研究基金资助项目(201207857)
【分类号】：R56;R446.5
【正文快照】： 呼吸道标本中分离出的1 623株铜绿假单胞菌对常用抗菌药物耐药性进行分析,现将结果报道如下。1材料与方法1.1临床资料2011-2013年病房及门诊呼吸道感染患者中共分离铜绿假单胞菌1 623株,其中2011年分离铜绿假单胞菌496株、2012年分离出496株、2013年分离出631株,见表1。表1 3

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