慢性阻塞性肺疾病急性加重期患者肺部感染应用噻托溴铵治疗的效果研究

发布时间：2018-01-10 18:07

本文关键词：慢性阻塞性肺疾病急性加重期患者肺部感染应用噻托溴铵治疗的效果研究　出处：《中华医院感染学杂志》2015年23期 　论文类型：期刊论文

【摘要】：目的探讨慢性阻塞性肺疾病(COPD)急性加重期患者肺部感染应用噻托溴铵治疗的效果,为临床治疗提供参考。方法随机选取2013年1月-2014年9月在医院接受治疗的慢性阻塞性肺疾病急性加重期并伴有轻、中度的肺部感染患者共80例作为研究对象,将其分为观察组和对照组各40例;对照组患者给予常规的治疗,观察组患者在此基础上联合噻托溴铵进行治疗,分析两组患者治疗效果,数据采用SPSS 18.0软件进行统计分析。结果两组患者治疗前的氧合指数(PaO2/FiO2)以及动脉血二氧化碳分压(PaCO2)水平比较差异无统计学意义,治疗后,观察组患者的氧合指数(PaO2/FiO2)明显高于对照组,而动脉血二氧化碳分压(PaCO2)明显低于对照组,两组比较差异有统计学意义(P0.05);观察组患者治疗的总有效率达到97.5%,明显高于对照组,两组比较差异有统计学意义(P0.05)。结论对于肺部感染的COPD急性加重期患者采用噻托溴铵进行治疗的效果显著,可以使肺功能得到显著改善,值得在临床上广泛使用并推广。
[Abstract]:Objective to investigate the chronic obstructive pulmonary disease (COPD) acute exacerbation of tiotropium bromide in treatment of patients with pulmonary infection during the application of the effect, to provide reference for clinical treatment. Methods randomly selected from January 2013 -2014 year in September in the hospital for treatment of chronic obstructive pulmonary disease with acute exacerbation and accompanied by light, with a total of 80 cases as the research object to moderate the lung infection, divided into the observation group and 40 cases in the control group; the control group were given routine treatment, the patients in the observation group were combined with tiotropium bromide treatment, analysis of treatment effect of two groups of patients, the data using SPSS 18 software for statistical analysis. Results of the two groups of patients before treatment of oxygen composite index (PaO2/FiO2) and partial pressure of arterial carbon dioxide (PaCO2) had no statistically significant differences in the levels of patients in the observation group after treatment, the oxygenation index (PaO2/FiO2) was significantly higher than the control group, and the arterial blood two oxidation The partial pressure of carbon (PaCO2) was significantly lower than the control group, there was significant difference between two groups (P0.05); the patients in the observation group the total effective rate was 97.5%, significantly higher than the control group, there was significant difference between two groups (P0.05). Conclusion the pulmonary infection in patients with acute exacerbation of COPD using tiotropium bromide treatment effect is remarkable, can make the lung function improved significantly, and it is widely used in clinical practice.

【作者单位】：解放军第89医院药剂科;
【基金】：山东省科技厅研究基金资助项目(SD12447-02456)
【分类号】：R563
【正文快照】： 慢性阻塞性肺疾病(COPD)是一种以不完全可逆气流受限为主要特征的肺部疾病,感染是COPD病情加剧的主要原因之一。COPD急性发作合并肺部感染对于患者的生命健康有着严重威胁,因此及时、有效治疗可提高患者存活率。COPD患者在常规治疗的基础上联合噻托溴铵进行治疗可明显的改善患

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