老年慢性阻塞性肺疾病患者B型钠尿肽水平变化的临床意义

发布时间：2018-01-22 10:37

本文关键词： 慢性阻塞性肺疾病肺动脉压力 B型钠尿肽　出处：《中国老年学杂志》2016年14期 　论文类型：期刊论文

【摘要】：目的探析血浆B型钠尿肽(BNP)水平在慢性阻塞性肺疾病(COPD)老年患者的预后及肺动脉压力(PAP)高压评估中的临床价值。方法 30例老年COPD患者为观察组,同期有呼吸困难、长期慢性咳嗽及咳痰症状但未达到COPD诊断标准的56例非COPD患者为对照组。比较两组一般资料、肺功能、血液检查及PAP,相关性分析血浆BNP水平与PAP的关系。结果两组性别及年龄无显著差异(P0.05)。观察组第1秒用力呼气容积实测值/预计值(FEV1%)、FEV1/用力肺活量(FVC)值明显比对照组低(P0.01);两组肺活量预计值(VC%)值相似(P0.05)。观察组内轻、中、重度的患者数量相当。观察组血浆BNP水平、PAP、门诊次数及住院时间均明显高于对照组(P0.01)。BNP与PAP行线性相关分析结果提示两者呈正相关(r=0.502,P=0.013)。结论 COPD老年患者的血浆BNP水平可以良好地体现其PAP水平,对病情评估及PAP监测有重要的临床意义。
[Abstract]:Objective to investigate the prognosis and pulmonary artery pressure (PAPP) of plasma B-type natriuretic peptide (BNPs) in elderly patients with chronic obstructive pulmonary disease (COPD). Methods 30 elderly patients with COPD were selected as the observation group. 56 patients with chronic cough and sputum who had dyspnea and chronic cough and sputum symptoms but did not meet the diagnostic criteria of COPD were compared with the control group. The general data, pulmonary function, blood test and PAP were compared between the two groups. Results there was no significant difference in sex and age between the two groups (P 0.05). Forced expiratory volume (FEV1) was measured / predicted at 1 seconds in the observation group. FEV1 / FVCvalue was significantly lower than that of control group (P 0.01). The predicted vital capacity value of the two groups was similar to that of the control group (P 0.05). The number of mild, moderate and severe patients in the observation group was the same. The plasma BNP level in the observation group was similar to that in the control group. The frequency of outpatient service and the length of hospitalization were significantly higher than those of control group (P 0.01). The results of linear correlation analysis between BNP and PAP showed that there was a positive correlation between them. Conclusion the level of plasma BNP in elderly patients with COPD can well reflect the level of PAP, which is of great clinical significance for the evaluation of the disease and the monitoring of PAP.
【作者单位】：海南省人民医院呼吸内科;
【基金】：海南省应用技术研发与示范推广专项(No.ZDXM2015073)
【分类号】：R563.9
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