支气管哮喘患者白细胞介素-33作用的临床研究

发布时间：2018-01-29 20:06

本文关键词： 支气管哮喘 IL- 免疫球蛋白E 嗜酸性粒细胞　出处：《中国现代医学杂志》2016年04期 　论文类型：期刊论文

【摘要】：目的分析支气管哮喘(简称哮喘)患者血清白细胞介素-33(IL-33)水平变化及临床意义。方法回顾性分析该院2013年3月-2015年3月住院的120例未治疗的哮喘急性发作期及治疗后缓解期的患者作为观察组,另选择80例健康者(健康体检人群)为对照组,分别对两组患者血清中IL-33的水平进行检测,并检测患者血清免疫球蛋白E(Ig E)及嗜酸性粒细胞(Eos)的水平,所有受试者均行肺功能检测(PTF)。结果与健康对照组比较,哮喘急性发作治疗前组血清中IL-33及IgE的水平、Eos的绝对数显著升高(P0.05);哮喘治疗后缓解组IL-33的水平与IgE的水平、Eos绝对计数呈正相关(P0.05),而与第1秒用力呼气容积(FEV1)、第1秒用力呼气量占用力肺活量比值(FEV1/FVC)、FEV1占预计值的百分比(FEV1%pre)均呈负相关(P0.05)。结论 IL-33积极参与了机体的炎症反应;调节IL-33可以作为支气管哮喘的治疗方法。
[Abstract]:Objective to analyze the serum levels of interleukin-33 (IL-33) in patients with bronchial asthma (Asthma). Methods from March 2013 to March 2015, 120 untreated patients with acute attack of asthma and post-treatment remission were retrospectively analyzed as observation group. Another 80 healthy people (healthy physical population) were selected as the control group, the serum IL-33 levels of the two groups were measured. The serum levels of serum immunoglobulin (Ig) and eosinophil (Eoso) were measured. The pulmonary function of all subjects was measured. The results were compared with those of the healthy control group. The levels of IL-33 and IgE in the serum of patients with acute asthma attack before treatment were significantly higher than those in the control group (P 0.05). There was a positive correlation between the level of IL-33 and the absolute count of IgE in the remission group after asthma treatment (P0. 05), but there was a positive correlation with the forced expiratory volume (FEV1) at 1 seconds (P < 0. 05). The ratio of forced expiratory volume to forced vital capacity at 1 seconds was FEV1 / FVC. The percentage of FEV1 to predicted value was negatively correlated with FEV1.Conclusion IL-33 is actively involved in the inflammatory reaction of the body. Regulation of IL-33 can be used as a treatment for bronchial asthma.
【作者单位】：广东省潮州市人民医院呼吸内科;
【分类号】：R562.25
【正文快照】： 支气管哮喘(bronchial asthma,BA,简称哮喘)氨基酸,分子质量为18 k Da。体外实验证明,IL-33是呼吸系统疾病的常见病、多发病,近年来呈逐年上以30 k Da的前体蛋白形式存在于细胞核内,经半胱升趋势,在我国支气管的患病率为1%~4%,是一种氨酸蛋白酶1(caspases-1)剪切加工成18 k Da

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