平喘固本汤加减联合家庭氧疗治疗慢性阻塞性肺疾病的疗效及其对患者认知功能障碍的影响

发布时间：2018-02-02 19:25

本文关键词： 平喘固本汤加减家庭氧疗慢性阻塞性肺疾病认知功能障碍　出处：《中国老年学杂志》2017年14期 　论文类型：期刊论文

【摘要】：目的探讨平喘固本汤加减联合家庭氧疗治疗稳定期慢性阻塞性肺疾病(COPD)的疗效及其对患者认知功能障碍预防的价值。方法80例稳定期COPD患者随机分为对照组和研究组各40例。对照组给予祛痰、平喘等常规治疗,研究组在对照组的基础上给予固本止咳平喘颗粒联合家庭氧疗治疗。测定两组治疗前后肺功能指标和动脉血气分析的变化,比较两组治疗前后呼吸困难(m MRC)、生活质量(SGRQ)以及认知功能(MMSE)评分,比较两组认知功能障碍的发生率。结果研究组治疗后m MRC和SGRQ评分,显著低于对照组,MMSE评分显著高于对照组(P0.05);研究组治疗后用力肺活量(FVC)、第1秒用力呼气量(FEV1)和最大呼气峰流速值(PEF)均显著高于对照组(P0.05);研究组治疗后动脉血氧分压(Pa O2)显著高于对照组,动脉二氧化碳分压(Pa CO2)显著低于对照组(P0.05);研究组治疗后认知功能障碍发生率显著低于对照组(P0.05)。结论平喘固本汤加减联合家庭氧疗治疗可在改善稳定期COPD患者肺功能的同时大大降低患者认知功能障碍的发生风险,改善患者的生活质量,值得临床应用。
[Abstract]:Objective to explore the treatment of stable chronic obstructive pulmonary disease (COPD) by combined therapy of Pingchuan Guben decoction and family oxygen therapy. Methods 80 patients with stable COPD were randomly divided into control group (n = 40) and study group (n = 40). On the basis of the control group, the study group was treated with Guben Zhike Pingchuan granule combined with family oxygen therapy. The changes of pulmonary function index and arterial blood gas analysis were measured before and after treatment in both groups. The scores of dyspnea, quality of life (QOL) and cognitive function (MMSE) were compared between the two groups before and after treatment. Results the scores of m MRC and SGRQ in the study group were significantly lower than those in the control group (P 0.05). After treatment, forced vital capacity (FV), forced expiratory volume (FEV1) and peak expiratory peak flow (PEFV) in the study group were significantly higher than those in the control group (P 0.05). After treatment, the arterial partial pressure of oxygen (Pao _ 2) in the study group was significantly higher than that in the control group, and the arterial partial pressure of CO _ (2) was significantly lower than that in the control group (P 0.05). The incidence of cognitive dysfunction in the study group was significantly lower than that in the control group (P 0.05). Conclusion the combination of Pingchuan Guben decoction and family oxygen therapy can improve the pulmonary function of patients with stable COPD and reduce the risk of cognitive dysfunction. It is worthy of clinical application to improve the quality of life of patients.
【作者单位】：海南省中医院呼吸科;
【基金】：海南省卫生和计划生育委员会科研基金项目(琼卫2011-85)
【分类号】：R563.9
【正文快照】： 慢性阻塞性肺疾病(COPD)好发于老年人。近年来随着吸烟人数增多、环境污染加剧及我国社会人口老龄化的进程,COPD的发病率呈逐年增长的趋势[1]。COPD具有高发病率、可进展性、反复发作、高致死率等特点,严重影响患者的身心健康和生活质量。研究显示,COPD除了对患者肺部造成损伤

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