益肺活血颗粒对慢性阻塞肺疾病稳定期患者血清炎症因子的影响及疗效观察

发布时间：2018-02-04 12:02

本文关键词： 益肺活血颗粒慢性阻塞肺疾病稳定期血清炎症因子　出处：《中国老年学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的探讨益肺活血颗粒对慢性阻塞肺疾病(COPD)稳定期患者的治疗效果及血清炎症因子的影响。方法选择2015~2016年该院收治的COPD稳定期患者80例,通过随机数表法分为观察组和对照组各40例,对照组给予常规治疗,观察组增加益肺活血颗粒。观察两组患者治疗前后血清炎症因子水平、肺功能、运动耐力、生活质量、症状积分的变化情况,并比较治疗后的临床疗效。结果治疗后,观察组白细胞介素(IL)-8、肿瘤坏死因子(TNF)-α、转换生长因子(TGF)-β1水平低于对照组;肺功能及运动耐力中,观察组第1秒用力呼吸容积(FEV1)、FEV1%、FEV1/肺活量(FVC)%、6 min行走距离(6MWT)均高于对照组;观察组生活质量总分、症状总积分均比对照组低,临床总有效率高于对照组(均P0.05)。结论COPD稳定期患者给予益肺活血颗粒的使用具有良好疗效,可有效使患者体内的血清炎症因子水平降低,改善肺功能,促进生活质量提高,值得应用推广。
[Abstract]:Objective to study the effect of Yifei Huoxue granule on chronic obstructive pulmonary disease (COPDD). Methods from 2015 to 2016, 80 patients with COPD in stable period were selected. The patients in the observation group were divided into two groups: the control group (n = 40) and the control group (n = 40). The patients in the control group were treated with routine therapy, and the patients in the observation group were treated with Yifei Huoxue granule. Changes of exercise endurance, quality of life, symptom score, and comparison of clinical efficacy after treatment. Results after treatment, the observation group interleukin-8, tumor necrosis factor TNF- 伪. The level of TGF- 尾 1 in TGF- 尾 1 was lower than that in control group. In the lung function and exercise endurance, the forced respiratory volume (FEV1) and FEV1 / vital capacity (FVCU) were measured at 1 seconds in the observation group. The walking distance of 6 min was higher than that of the control group. The total score of quality of life and the total score of symptoms in the observation group were lower than those in the control group. The total clinical effective rate was higher than that of the control group (all P0.050.Conclusion the use of Yifei Huoxue granule in patients with COPD at stable stage has a good curative effect and can effectively reduce the level of serum inflammatory factors in patients. Improving lung function and promoting quality of life is worth popularizing.
【作者单位】：济南市第三人民医院重症监护室;山东大学附属济南中心医院肾脏血液净化科;
【分类号】：R563.9
【正文快照】： 1山东大学附属济南中心医院肾脏血液净化科慢性阻塞肺疾病(COPD)在临床上常见且多发,该病的发病机制在临床上未得到明确的阐述,但许多学者提出其与肺部对香烟、烟雾等产生的有害气体或颗粒的异常严重存在着密切的相关性〔1〕。有研究显示,COPD患者血清炎症因子水平高表达〔2〕

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