沙美特罗替卡松与氨茶碱联合治疗对慢性阻塞性肺病急性加重期疗效和氧化应激的影响

发布时间：2018-02-09 00:46

本文关键词： 沙美特罗替卡松氨茶碱慢性阻塞性肺疾病急性加重期肺功能氧化应激　出处：《中国现代医学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的探讨沙美特罗替卡松联合氨茶碱治疗慢性阻塞性肺病急性加重期(AECOPD)疗效及对患者肺功能和氧化应激的影响。方法选取2014年1月-2015年9月于重庆三峡中心医院接受治疗的200例AECOPD患者作为研究对象,按照随机数字表法随机分为对照组(n=100)和观察组(n=100)。所有患者均给予常规治疗,在此基础上,对照组给予氨茶碱治疗,观察组在对照组的基础上联合应用沙美特罗替卡松治疗。疗程结束后,比较两组患者临床疗效、肺功能、氧化应激水平及不良反应情况。结果疗效评价后,观察组治疗总有效率高于对照组(95.0%vs 86.0%,P0.05)。治疗后,与对照组比较,观察组患者肺功能指标FEV1、FEV1/FVC升高,氧化应激指标MDA水平下降,SOD、GSH-Px水平升高,组间比较差异有统计学意义(P0.05)。治疗期间,对照组和观察组患者均未出现严重不良反应。结论沙美特罗替卡松联合氨茶碱治疗AECOPD疗效良好,能够明显提高临床疗效,改善肺功能,减轻氧化应激,且不良反应轻微,临床上值得应用。
[Abstract]:Objective to investigate the efficacy of salmeterol and aminophylline in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD) and its effect on pulmonary function and oxidative stress. Two hundred patients with AECOPD received treatment as subjects. According to the random number table method, the patients in the control group were randomly divided into two groups, the control group and the observation group. All the patients were given routine treatment, and the control group was treated with aminophylline, and the control group was treated with aminophylline. The observation group was treated with salmeterolticasone on the basis of the control group. After the course of treatment, the clinical efficacy, lung function, oxidative stress level and adverse reaction were compared between the two groups. The total effective rate of treatment in the observation group was higher than that in the control group (95.0 vs 86.0). After treatment, compared with the control group, the pulmonary function index FEV1 / FEV1 / FVC in the observation group increased, the level of MDA decreased and the level of GSH-Px increased. There was a significant difference between the two groups during the treatment period. Conclusion salmeterol combined with aminophylline is effective in the treatment of AECOPD, which can significantly improve the clinical efficacy, improve lung function, alleviate oxidative stress, and the adverse reaction is mild. It is worth applying clinically.
【作者单位】：重庆三峡中心医院老年科;
【分类号】：R563.9

【参考文献】