血清IgE水平在慢性阻塞性肺疾病急性加重患者治疗中的意义

发布时间：2018-02-11 19:39

  本文关键词： 慢性阻塞性肺疾病 IgE 糖皮质激素　出处：《中国老年学杂志》2014年11期 　论文类型：期刊论文

【摘要】：目的探讨慢性阻塞性肺疾病急性加重(AECOPD)患者吸入性糖皮质激素疗效与血IgE水平的关系。方法将176例AECOPD病例随机分为两组,均予常规抗生素、吸氧治疗,激素吸入组在此基础上增加吸入布地奈德2 mg,2次/d,治疗1 w,治疗前后行肺功能、血气分析检查并比较两组的血IgE水平;此外,激素吸入组在治疗前按疾病程度分为Ⅰ级(27例)、Ⅱ级(31例)、Ⅲ级(30例)。将AECOPD组患者按照临床及动脉血气分析指标分为改善组54例及无明显缓解组34例,比较不同分级及预后患者的血IgE水平。结果治疗前两组的血IgE水平差异无统计学意义(P0.05),治疗前后两组内部比较IgE值均降低(均P0.01),治疗后吸入组的血IgE水平低于常规治疗组(t=9.933,P0.01);三组治疗前的血IgE水平比较差异无统计学意义(F=0.285,P=0.792),治疗后三组的血IgE水平下降(P0.01),三组治疗前后差值比较差异无统计学意义(F=0.145,P0.05);吸入组患者治疗后症状改善组血IgE水平低于无明显改善组(t=19.795,P0.01)。结论 AECOPD患者血IgE水平升高,吸入糖皮质激素可缓解临床症状及改善肺功能,降低血IgE水平,但血IgE水平的高低与AECOPD病情的严重程度不成正比。
[Abstract]:Objective to investigate the relationship between the effect of inhaled glucocorticoid and the level of serum IgE in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods 176 cases of AECOPD were randomly divided into two groups. On this basis, the hormone inhaled group increased the inhaled budesonide 2 mg / d for 1 week. Lung function, blood gas analysis and blood gas analysis were performed before and after treatment. In addition, blood IgE levels were compared between the two groups. According to the degree of disease, the hormone inhalation group was divided into three groups according to the degree of disease: 27 cases of grade 鈪，

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