COPD纤维支气管镜肺泡灌洗液中可溶性晚期糖基化终末产物受体水平的临床意义

发布时间：2018-02-12 11:13

本文关键词： 肺疾病慢性阻塞性支气管肺泡灌洗液可溶性晚期糖基化终末产物　出处：《中国全科医学》2014年24期 　论文类型：期刊论文

【摘要】：目的探讨纤维支气管镜肺泡灌洗液中可溶性晚期糖基化终末产物受体(sRAGE)水平在COPD中的临床意义。方法选取2012年10月—2013年5月入住辽宁医学院附属第一医院重症监护病房COPD患者40例为COPD组,另选取同时期非COPD组患者40例为非COPD组;将COPD患者分为轻度COPD组(12例)、中度COPD组(10例)、重度COPD组(10例)、极重度COPD组(8例)。采用酶联免疫吸附试验(ELISA)方法检测纤维支气管镜肺泡灌洗液中sRAGE水平。结果 COPD组患者纤维支气管镜肺泡灌洗液sRAGE水平为(191±71)ng/L,高于非COPD组的(55±56)ng/L(t=9.44,P0.001)。轻度COPD组纤维支气管镜肺泡灌洗液sRAGE水平为(111±44)ng/L、中度COPD组为(184±45)ng/L、重度COPD组为(226±34)ng/L、极重度COPD组为(273±30)ng/L,差异有统计学意义(F=30.48,P0.001),且极重度COPD组高于重度COPD组,重度COPD组高于中度COPD组,中度COPD组高于轻度COPD组(P0.05)。直线相关分析结果显示,COPD患者纤维支气管镜肺泡灌洗液sRAGE水平与一秒用力呼气容积占预计值百分比(FEV1%)呈负相关(r=-0.738,P0.05)。结论 COPD患者纤维支气管镜肺泡灌洗液中sRAGE水平较非COPD患者增高,纤维支气管镜肺泡灌洗液中sRAGE水平与COPD病情严重程度有关,可作为评价COPD预后的一个指标。
[Abstract]:Objective to investigate the clinical significance of soluble advanced glycosylation end product receptor (sRAGE) in bronchoalveolar lavage fluid (BALF) in COPD. Methods from October 2012 to May 2013, we were admitted to the intensive care unit of the first affiliated Hospital of Liaoning Medical College. 40 patients with COPD in nursing ward were treated with COPD. In addition, 40 cases of non COPD group were selected as non COPD group at the same time. The patients with COPD were divided into mild COPD group (n = 12), moderate COPD group (n = 10), severe COPD group (n = 10) and severe COPD group (n = 8). The level of sRAGE in bronchoalveolar lavage fluid (BALF) was detected by Elisa. Results COPD. The sRAGE level of bronchoalveolar lavage fluid in the mild COPD group was 111 卤44ng / L, that in the moderate COPD group was 184 卤45ng / L, that in the severe COPD group was 226 卤34ng / L, and that in the very severe COPD group was 273 卤30ngr / L, respectively. The clinical significance was 30.48% (P 0.001), and that of very severe COPD group was higher than that of severe COPD group. Severe COPD group was higher than moderate COPD group. Linear correlation analysis showed that the level of sRAGE in bronchoalveolar lavage fluid was negatively correlated with the percentage of forced expiratory volume to predicted value at 1 second in moderate COPD group than that in mild COPD group. Conclusion there is a negative correlation between sRAGE level and forced expiratory volume (FEV1) in patients with COPD. Conclusion Fiber-bronchitis in COPD patients is significantly higher than that in mild COPD group (P < 0.05). The level of sRAGE in bronchoalveolar lavage fluid was higher than that in non-#en1# patients. The level of sRAGE in bronchoalveolar lavage fluid is related to the severity of COPD. It can be used as an index to evaluate the prognosis of COPD.
【作者单位】：辽宁医学院附属第一医院重症医学科;辽宁医学院研究生学院;
【基金】：辽宁省教育厅科学技术研究项目(2008419)
【分类号】：R563.9

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