维生素D联合阿奇霉素对2型糖尿病患者肺炎的影响

发布时间：2018-02-13 02:29

  本文关键词： 维生素D 阿奇霉素 型糖尿病 肺炎 白细胞介素 C反应蛋白 免疫球蛋白G　出处：《中国药房》2017年32期 　论文类型：期刊论文

【摘要】：目的:探讨维生素D联合阿奇霉素治疗2型糖尿病患者肺炎的临床疗效和安全性,及其对血清炎症指标的影响。方法:选取我院2014年5月-2015年9月收治的2型糖尿病伴肺炎患者68例,按照随机数字表法将患者分为对照组和试验组,各34例。两组患者均给予胰岛素强化降糖。对照组患者给予注射用阿奇霉素10 mg/kg+0.9%氯化钠注射液500 m L,ivgtt,qd,连续应用5 d后改用阿奇霉素干混悬剂10 mg/kg,po,qd,连用3 d后停药4 d为1个疗程,给药2个疗程;试验组患者在对照组基础上给予维生素D滴剂800单位,po,qd,连续给药4周。观察两组患者的临床疗效、治疗前后的血清炎症指标[白细胞介素6(IL-6)、C反应蛋白(CRP)和免疫球蛋白G(Ig G)]水平,并记录不良反应发生情况。结果:试验组患者临床总有效率(91.18%)显著高于对照组(70.59%),差异有统计学意义(P0.05)。治疗前,两组患者IL-6、CRP和Ig G等血清炎症指标比较,差异均无统计学意义(P0.05)。治疗后,两组患者IL-6和CRP均显著降低,且试验组显著低于对照组;两组患者Ig G显著升高,且试验组显著高于对照组,差异均有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:维生素D联合阿奇霉素治疗2型糖尿病患者肺炎的临床效果显著,有助于改善其血清IL-6、CRP和Ig G等炎症因子水平,且安全性较高。
[Abstract]:Objective: to investigate the clinical efficacy and safety of vitamin D combined with azithromycin in the treatment of pneumonia in patients with type 2 diabetes mellitus. Methods: from May 2014 to September 2015, 68 patients with type 2 diabetes mellitus with pneumonia were divided into control group and experimental group. The control group was given azithromycin 10 mg/kg 0.9% sodium chloride injection 500ml / L iv iv GTT QD for 5 days and the control group received azithromycin dry suspension 10 mg / kg popoqd for 3 days after continuous use of azithromycin 10 mg / kg poxaqd. the patients in the control group were given azithromycin 10 mg/kg 0.9% sodium chloride injection iv iv GTT QD for 5 days. 4 days was a course of treatment. The patients in the test group were treated with 800 units of vitamin D drops for 4 weeks. The clinical efficacy of the two groups was observed. Before and after treatment, the levels of serum inflammatory markers [Interleukin-6, IL-6, C-Reactive protein (CRP) and immunoglobulin G (IGG)], Results: the total effective rate of the patients in the trial group was significantly higher than that in the control group (70.59g), and the difference was statistically significant (P 0.05). Before treatment, serum inflammatory indexes such as IL-6 CRP and IgG were compared between the two groups. After treatment, the IL-6 and CRP of the two groups were significantly lower than those of the control group, and that of the two groups were significantly higher than that of the control group, and that of the two groups was significantly higher than that of the control group. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion: the clinical effect of vitamin D combined with azithromycin on patients with type 2 diabetes mellitus pneumonia is significant. It is helpful to improve the levels of inflammatory cytokines such as IL-6, CRP and IgG, and the safety is higher.
【作者单位】： 唐山市协和医院老年病科;
【基金】：唐山市科技计划项目(No.121302126a)
【分类号】：R563.1;R587.1
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本文编号：1507117