趋化性细胞因子及一氧化氮与呼吸道感染关系分析

发布时间：2018-02-13 09:59

本文关键词： 趋化性细胞因子一氧化氮呼吸道感染　出处：《中国免疫学杂志》2014年12期 　论文类型：期刊论文

【摘要】：目的:本研究旨在探讨趋化性细胞因子及一氧化氮水平变化与呼吸道感染的关系。方法:选取2012年8月至2013年8月期间我院呼吸内科收治的细菌性呼吸道感染患者40例作为观察组,同期健康研究对象30例作为观察组,比较观察组在入院时、入院后第3天、入院后第7天、出院时的细胞因子(TNF-α)、一氧化氮(NO)及白细胞介素(IL-6、IL-17、IL-10)水平差异,并分别同对照组进行比较。结果:观察组患者在入院时、入院后第3天、入院后第7天、出院时的TNF-α、NO、IL-6、IL-17、IL-10水平比较差异均具有统计学意义(F=10.849,P0.05),随着治疗时间的延长,患者呼吸道感染症状逐渐好转直至出院,可以发现上述各指标均随时间的延长而逐渐下降;观察组入院后第3天、入院后第7天、出院时的TNF-α、NO、IL-6、IL-17、IL-10水平分别与入院时比较差异均具有统计学意义(P0.05)。结论:通过测定呼吸道感染患者的细胞因子水平及NO水平,可以判断患者的病情转归程度。
[Abstract]:Objective: to investigate the relationship between the changes of chemokine and nitric oxide levels and respiratory tract infection. Methods: from August 2012 to August 2013, bacterial respiratory tract infection (BRTI) in our hospital was selected. 40 cases were used as observation group, In the same period, 30 healthy subjects were used as observation group. The levels of cytokine TNF- 伪, nitric oxide (no) and interleukin-6IL-17 (IL-10) were compared at admission, 3 days after admission, 7 days after admission, and 7 days after admission in the observation group, and the levels of TNF- 伪, nitric oxide (no) and interleukin-6IL-17 (IL-10) were compared between the observation group and the control group. Results: there were significant differences in the levels of IL-17 IL-10 between the two groups on admission, 3 days after admission, 7 days after admission, and 7 days after admission. There were statistically significant differences in the levels of IL-17 IL-10 between the two groups. With the prolongation of the treatment time, there were significant differences in the levels of IL-17 and IL-10 between the patients in the observation group and those in the control group, and there were significant differences in the levels of IL-17 and IL-10 between the two groups. The symptoms of respiratory tract infection were gradually improved until discharge from hospital, and it was found that the above indexes decreased gradually with the prolongation of time, while in the observation group, the symptoms of respiratory tract infection were gradually improved 3 days after admission and 7 days after admission. The levels of IL-17 IL-10 in patients with TNF- 伪, IL-6 and IL-6 were significantly different from those at admission (P 0.05). Conclusion: the level of cytokines and no in patients with respiratory tract infection can be determined by measuring the level of cytokines and the level of no in patients with respiratory tract infection.
【作者单位】：陕西中医学院;第四军医大学唐都医院呼吸科;
【分类号】：R56

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