特异性肺纤维化和体液免疫指标对尘肺病晋期诊断价值分析

发布时间：2018-02-15 15:47

本文关键词： 尘肺病晋期肺纤维化体液免疫血管紧张素转化酶铜蓝蛋白补体免疫球蛋白　出处：《中国职业医学》2014年04期 　论文类型：期刊论文

【摘要】：目的探讨特异性肺纤维化和体液免疫指标对于尘肺晋期进展的辅助诊断价值。方法以2005年1月至2014年1月在本院住院的尘肺病患者为研究对象,根据是否晋期分为晋期组(27例)与对照组(27例),收集2组患者首次诊断和晋期诊断时的特异性肺纤维化指标血管紧张素转化酶(ACE)、单胺氧化酶(MAO)、铜蓝蛋白(CP)和体液免疫指标免疫球蛋白(Ig)A、IgG、IgM、补体3(C3)、补体4(C4)、C反应蛋白(CRP)的检查结果。计量资料采用以中位数和第25、75百分位数描述,采用秩和检验和二分类非条件Logistic回归分析进行统计分析。结果晋期组晋期诊断时ACE活力和CP、C3、C4、IgG水平均高于首次诊断[94.00(69.00,123.00)vs 68.00(46.80,89.00)U/L,322.90(274.00,411.80)vs 283.80(248.00,336.00)mg/L,1.33(1.16,1.51)vs 1.12(0.93,1.31)g/L,0.33(0.28,0.37)vs 0.28(0.22,0.34)g/L,12.31(10.56,14.14)vs 10.24(9.08,11.90)g/L,P0.05)]。晋期组晋期诊断时与首次诊断时的ACE、C3、C4和IgG的指标差值分别高于对照组相应的指标差值[30.00(-2.50,44.20)vs-8.00(-42.00,11.00)U/L,0.20(0.12,0.31)vs-0.14(-0.29,0.06)g/L,0.05(-0.01,0.08)vs0.01(-0.02,0.04)g/L,1.02(-0.61,3.81)vs 0.70(-3.59,1.53)g/L,P0.05)]。Logistic回归分析结果显示,晋期诊断和首次诊断时C3和ACE的指标差值越大者,发生尘肺病晋期的危险性越高(P0.05)。结论晋期组患者存在肺纤维化持续加重和体液免疫亢进。特异性肺纤维化和体液免疫指标对尘肺晋期进展的辅助诊断有一定价值,需要动态监测、综合分析。
[Abstract]:Objective to investigate the value of specific pulmonary fibrosis and humoral immunity in the diagnosis of pneumoconiosis progression. Methods patients with pneumoconiosis hospitalized in our hospital from January 2005 to January 2014 were studied. According to whether the early stage was divided into two groups (27 cases) and the control group (27 cases), the specific markers of angiotensin converting enzyme (ACEE), monoamine oxidase (MAOO), ceruloplasmin (CPP) and humoral fluid were collected for the first diagnosis and diagnosis of the two groups. The examination results of immunoglobulin (IgA) IgGN IgM, complement 3C _ (3), complement 4C _ (4) and C-reactive protein (CRP) were measured in terms of median and 2575th percentile. Results the activity of ACE and the level of CPC3C4G in Jin group were higher than those in the first diagnosis [94.0069.00123.00 vs 68.0069.00123.00 vs 68.006.808.800.9022.274.00411.80 vs 283.80248.00 336.00 mg / L 1.331.331.151 vs 1.120.933.31g / L 0.330.37 vs 0.280.220.220.34g / L = 12.31g / L 12.31g / L = 10.5614.14 vs 249.811.90g / L P 0.05t = 249.811.90g / L / L = 249.811.90g / g / g / r. The difference between C _ 3C _ 4 and IgG was higher than that of the control group respectively [30.00-2.50 ~ 44.20vs-8.00n- 42.0011.0011.00U / L 0.200.120.31vs-0.14n- 0.290.29 ~ 0.06g / L 0.06g / L 0.08vs0.08vs0.08vs0.08vs0.08g / L 1.02n -0.61g / L = 0.70-3.59g / L = 0.70-3.59g / L = 1.53g / L = 0.05). Logistic regression analysis showed that. The greater the difference between C3 and ACE in diagnosis and the first diagnosis, The higher the risk of developing pneumoconiosis is, the higher the risk of developing pneumoconiosis is (P 0.05). Conclusion Pulmonary fibrosis and humoral immunity hyperfunction exist in the patients in Jin period group. The specific pulmonary fibrosis and humoral immunity indexes have some value in the auxiliary diagnosis of the progression of pneumoconiosis in the early stage of pneumoconiosis. Need dynamic monitoring, comprehensive analysis.
【作者单位】：广东省职业病防治院广东省职业病防治重点实验室;
【基金】：国家临床重点专科建设项目(2011-09) 广东省职业病防治重点实验室(2012A061400007)
【分类号】：R135.2

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