个体化肠内营养结合呼吸康复治疗对AECOPD患者治疗作用的研究

发布时间：2018-02-22 05:45

本文关键词： 个体化肠内营养呼吸康复肺功能 CAT 淋巴细胞绝对值　出处：《山西医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:慢阻肺是一种气流受限不完全可逆的,呈进行性发展的肺部疾病,延缓此类患者肺功能的进展至关重要,药物治疗有一定的局限性,在此基础上新的治疗方案有待研究。本研究通过观察常规治疗基础上的个体化肠内营养结合呼吸康复治疗对急性加重期慢阻肺(AECOPD)患者肺功能、营养状况、免疫功能、生活状况的改善,评价其对AECOPD的治疗意义及价值,为AECOPD的临床治疗增添新的思路。方法:本研究为临床随机对照研究。收集山西省汾阳医院2015-10至2016-5期间80例AECOPD的患者,随机分组(两组各40例)。实验组行呼吸康复治疗+个体化肠内营养+常规治疗,对照组行常规对症支持治疗+常规饮食治疗。两组患者均治疗14天。治疗前后对患者进行慢阻肺生活评分量表(CAT)评分,并测定肺功能、淋巴细胞数及营养状况相关指标。对结果进行统计分析并得出结论。结果:(1)两组患者治疗前肺功能(FEV1、FVC)、血清前白蛋白、血清白蛋白、CAT、淋巴细胞比较,差异无统计学意义(P0.05)。(2)两组患者治疗后FEV1、血清前白蛋白、血清白蛋白均得到改善,差别具有统计学意义(P0.01),实验组治疗后效果较对照组显著(P0.01)。(3)两组患者治疗后FVC得到改善,差别具有统计学意义(P0.01),实验组治疗后效果较对照组无明显差异(P=0.94)。(4)实验组患者治疗后CAT、淋巴细胞得到改善,差别具有统计学意义(P0.01),对照组患者治疗前后无明显差别(P0.05)。结论:与常规治疗相比,联合个体化肠内营养和呼吸康复治疗方案可有效改善肺功能、免疫功能及营养状态,提高患者生活质量。
[Abstract]:Objective: chronic obstructive pulmonary disease (COPD) is a kind of pulmonary disease which is not completely reversible with airflow limitation. It is very important to delay the progress of pulmonary function in these patients. In this study, the effects of individual enteral nutrition combined with respiratory rehabilitation on pulmonary function, nutritional status and immune function in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) were studied. The improvement of living conditions, the evaluation of its significance and value in the treatment of AECOPD, and the addition of new ideas for the clinical treatment of AECOPD. Methods: this study is a randomized controlled clinical study. 80 patients with AECOPD were collected from 2015-2016-5 in Fenyang Hospital of Shanxi Province. Two groups (40 cases each) were randomly divided into two groups. The experimental group was treated with routine therapy of individual enteral nutrition after respiratory rehabilitation. The patients in the control group were treated with routine diet therapy. The patients in both groups were treated for 14 days. Before and after treatment, the patients were assessed with chronic obstructive pulmonary life scale (COPD) and the pulmonary function was measured. The results were statistically analyzed and concluded. Results the pulmonary function of the two groups was compared before treatment with FEV1 FVCV, serum prealbumin, serum albumin, CAT and lymphocyte. There was no significant difference in FEV1, serum prealbumin and serum albumin between the two groups after treatment. The difference was statistically significant. The effect of the experimental group was significantly higher than that of the control group. The difference was statistically significant (P 0.01). There was no significant difference between the experimental group and the control group (P < 0. 94, P 0. 94, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01). The difference was statistically significant (P 0.01), but there was no significant difference between the control group and the control group before and after treatment. Conclusion: compared with routine treatment, the combination of individualized enteral nutrition and respiratory rehabilitation can effectively improve lung function, immune function and nutritional status. Improve the quality of life of patients.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R563.9

【参考文献】