涂阳肺结核患者抗结核药物不良反应发生影响因素分析

发布时间：2018-02-27 05:16

  本文关键词： 涂阳肺结核 抗结核药物 治疗 不良反应 影响因素　出处：《中国人兽共患病学报》2016年12期 　论文类型：期刊论文

【摘要】：目的探讨涂阳肺结核患者接受抗结核药物治疗的不良反应发生情况及其影响因素,为制定结核病防治策略提供参考。方法选择2008—2010年我国8个省(市、自治区)结核病定点医疗机构治疗诊治的涂阳肺结核患者共2 142例,根据是否发生不良反应将其分为两组,运用卡方检验单因素及logistic多因素回归对不良反应发生的危险因素进行分析。结果2 142例涂阳肺结核患者中536例患者出现不良反应,不良反应发生率为25.0%。经单因素分析结果表明年龄(χ2=23.815,P0.001)、吸烟情况(χ2=12.040,P=0.024)及结果差异均有统计学意义。多因素非条件logistic回归结果显示,45~64岁和≥65岁年龄组及吸烟是不良反应发生的独立危险因素,OR(95%CI)值分别为1.524(1.159~2.422)和1.756(1.200~2.570)及1.620(1.194~2.198)。结论涂阳肺结核患者中吸烟及中老年人是发生不良反应的危险因素,在患者诊治过程中,应及时对这类高危人群进行监测和主动干预,对发现和降低不良反应的发生率有着重要意义。
[Abstract]:Objective to investigate the incidence of adverse reactions of smear positive pulmonary tuberculosis patients receiving anti-tuberculosis drug therapy and its influencing factors, and to provide a reference for the formulation of tuberculosis prevention and control strategies. Methods eight provinces (cities) were selected from 2008 to 2010 in China. A total of 2,142 smear positive pulmonary tuberculosis patients were treated by designated medical institutions in the autonomous region. They were divided into two groups according to whether or not adverse reactions occurred. The risk factors of adverse reactions were analyzed by chi-square test single factor and logistic multivariate regression. Results 536 of 2142 smear positive pulmonary tuberculosis patients had adverse reactions. The incidence of adverse reactions was 25.0.The results of univariate analysis showed that age (蠂 ~ 2o 23.815), smoking status (蠂 ~ 2 + 12.040 P ~ (0.024)) and the difference of the results were statistically significant. Multivariate non-conditional logistic regression analysis showed that the age group of 4564 years old and 鈮，

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