明胶海绵颗粒和壳聚糖α,β-甘油磷酸凝胶微球在肺结核咯血应用中的对比

发布时间：2018-02-28 08:25

本文关键词：结核肺明胶海绵吸收性壳聚糖组织工程生物材料材料相容性明胶海绵颗粒壳聚糖/α β-甘油磷酸凝胶微球动物模型肺结核咯血生物相容性肺结核天津市自然科学基金　出处：《中国组织工程研究》2017年18期 　论文类型：期刊论文

【摘要】：背景:文献报道显示,明胶海绵颗粒和壳聚糖/α,β-甘油磷酸凝胶微球在肺结核咯血中具有较高的应用前景。目的:观察明胶海绵颗粒和壳聚糖/α,β-甘油磷酸凝胶微球在肺结核咯血中的应用效果。方法:取40只昆明小鼠,采用雾化吸入感染装置构建肺结核咯血模型,随机分为2组,分别采用明胶海绵颗粒、壳聚糖/α,β-甘油磷酸凝胶微球进行栓塞止血治疗,治疗后15,30 d,观察体质量变化、止血时间、止血有效率、心肌相关指标及肺结核组织病理变化。结果与结论:(1)壳聚糖/α,β-甘油磷酸凝胶微球组治疗后15 d的体质量高于明胶海绵组(P0.05);(2)壳聚糖/α,β-甘油磷酸凝胶微球组止血有效率高于明胶海绵组(P0.05),止血时间短于明胶海绵组(P0.05);(3)两组N端BNP前体、肌酸激酶同工酶及肌酸激酶水平比较差异无显著性意义(P0.05);(4)壳聚糖/α,β-甘油磷酸凝胶微球组材料周围淋巴细胞浸润,存在坏死病灶,材料上存在大量活性细胞;明胶海绵颗粒组材料上存在少许淋巴细胞,存在坏死病灶;(5)结果表明,将壳聚糖/α,β-甘油磷酸凝胶微球应用于肺结核小鼠动物模型中可获得更好的止血效果。
[Abstract]:Background: literature reports show that, Gelatin sponge granules and chitosan / 伪, 尾-glycerophosphate gel microspheres have high application prospects in hemoptysis of pulmonary tuberculosis. Objective: to observe the application of gelfoam granules and chitosan / 伪, 尾-glycerophosphate gel microspheres in hemoptysis of pulmonary tuberculosis. Methods: 40 Kunming mice were selected. Pulmonary tuberculosis hemoptysis model was established by atomization inhalation infection device, and was randomly divided into two groups. Gelatin sponge granules, chitosan / 伪, 尾 -glycerophosphate gel microspheres were used for embolization and hemostasis treatment. The changes of body mass and hemostatic time were observed at 1530 days after treatment. The effective rate of hemostasis, Results and conclusion the weight of chitosan / 伪, 尾 -glycerophosphate gel microspheres group 15 days after treatment was higher than that of gelatin sponge group (P 0.05) chitosan / 伪, 尾 -glycerophosphate gel microsphere group was effective in hemostasis. The hemostatic time was shorter than that in gelfoam group (P 0.05)) the N-terminal BNP precursor in the two groups was higher than that in the gelfoam group, and the hemostatic time was shorter than that in the gelatin sponge group. There was no significant difference in creatine kinase isoenzyme and creatine kinase level between the two groups. There was no significant difference in the levels of creatine kinase isoenzyme and creatine kinase (P 0.05). There were lymphocytes infiltrating around the materials in the chitosan / 伪, 尾 -glycerophosphate gel microspheres group, and there were necrosis of the lesions and a large number of active cells in the materials. The results showed that chitosan / 伪, 尾 -glycerophosphate gel microspheres could obtain better hemostatic effect in pulmonary tuberculosis mice model.
【作者单位】：天津医科大学;天津海河医院结核科;
【基金】：天津市自然科学基金资助项目(15ZCDZSY102201)~~
【分类号】：R318.08;R521

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