中国南方人群2型糖尿病与肺通气功能减退的关系

发布时间：2018-03-01 13:05

本文关键词： 型糖尿病肺通气功能减退关联研究 COPD　出处：《广东医学》2017年18期 　论文类型：期刊论文

【摘要】：目的了解2型糖尿病对肺通气功能减退及慢性阻塞性肺疾病(COPD)的影响,为2型糖尿病综合干预提供依据。方法运用1∶1匹配病例对照研究方法,肺功能仪以及自制问卷现场检测和调查病例对照间肺功能与相关影响因素情况。结果共招募216对2型糖尿病病例及配对对照,用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、第1秒用力呼气量占用力肺活量比值(FEV1/FVC)、用力呼气中期流速(FEF_(25-75))及呼气峰值流速(PEF)在病例组分别为(2.62±0.97)L、(2.02±0.78)L、0.77±0.10、(1.99±1.03)L/s和(5.20±2.09)L/s,在对照组分别为(2.63±0.90)L、(2.01±0.77)L、0.76±0.12、(1.90±1.07)L/s和(5.20±2.25)L/s,两组间分布差异无统计学意义(P0.05)。调整影响因素后,2型糖尿病并未增加阻塞性肺通气功能减退(OR=0.94,95%CI:0.54~1.66)和限制性肺通气功能减退(OR=1.09,95%CI:0.57~2.10)的发生风险;另外2型糖尿病也未增加COPD的发病风险(OR=1.37,95%CI:0.73~2.57)。结论中国南方人群中2型糖尿病并未导致肺通气功能减退及COPD的发病风险增加。
[Abstract]:Objective to investigate the effect of type 2 diabetes on pulmonary ventilation dysfunction and chronic obstructive pulmonary disease (COPD), and to provide evidence for comprehensive intervention of type 2 diabetes. Pulmonary function instrument and self-made questionnaire were used to detect and investigate the lung function and related influencing factors among case controls. Results 216 cases of type 2 diabetes mellitus and matched control group were recruited. Forced vital capacity (FV C), forced expiratory volume (FEV 1) at 1 seconds, forced expiratory volume / forced vital capacity ratio (FEV 1 / FV C) at 1 seconds, forced midexpiratory flow (FEFF 25-75) and peak expiratory flow (PEF) were 2.62 卤0.97 L 2.02 卤0.78 L 0.77 卤1.99 卤1.03L / s and 5.20 卤2.09L / s respectively in the case group, and 2.63 卤0.90 L / s 2.01 卤0.77L 0.76 卤0.76 卤1.90 卤1.07L / s and 5.20 卤2.25L / s in the control group, respectively. There was no significant difference in distribution between the two groups (P 0.05). After adjusting for the influencing factors, type 2 diabetes did not increase the risk of obstructive pulmonary ventilation dysfunction (OR0.94 + 95 CI: 0.54 / 1.66) and restricted pulmonary ventilation dysfunction (OR1.09 / 95 CI: 0.57 卤2.10). In addition, type 2 diabetes did not increase the risk of COPD. Conclusion Type 2 diabetes did not cause pulmonary ventilation dysfunction and increase the risk of COPD in southern Chinese.
【作者单位】：深圳市光明新区疾病预防控制中心慢性病防治科;深圳市疾病预防控制中心分子室;深圳市龙岗中心医院呼吸内科;
【基金】：广东省自然科学基金资助项目(编号:2014A030310091) 市科技计划项目(编号:JCYJ20150403095530583)
【分类号】：R563.9;R587.1

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