抗菌药物序贯治疗老年下呼吸道感染的临床研究

发布时间：2018-03-04 08:23

本文选题：抗菌药物　切入点：序贯疗法　出处：《中华医院感染学杂志》2014年15期 　论文类型：期刊论文

【摘要】：目的研究抗菌药物序贯治疗老年中重度下呼吸道感染的临床效果及经济效益,为临床资料提供参考依据。方法选取2010年1月-2011年10月医院诊治的80例中重度下呼吸道感染60岁的老年患者,随机分为试验组和对照组,各40例,其中试验组采用序贯疗法,对照组采用常规疗法,观察两组患者的疗效,并运用药物经济学成本-效果分析法对其经济效益进行评价。结果试验组治愈13例、显效15例,总有效率为87.5%;对照组治愈7例、显效13例,总有效率为72.5%;临床体征好转时间、平均住院时间及静脉治疗时间试验组均短于对照组,且平均住院费用与抗菌药物费用也均少于对照组;上述数据比较,差异均有统计学意义(P0.05)。结论对老年中重度下呼吸道感染患者应用抗菌药物序贯疗法可以有效治疗疾病,且具有良好的经济效益,序贯疗法的最佳转换时间约为7d。
[Abstract]:Objective to study the clinical effect and economic benefit of sequential treatment of senile moderate and severe lower respiratory tract infection with antimicrobial agents. Methods from January 2010 to October 2011, 80 patients aged 60 years old with moderate and severe lower respiratory tract infection were randomly divided into two groups, 40 cases in each group. The control group was treated with routine therapy, the curative effect of the two groups was observed, and its economic benefit was evaluated by pharmacoeconomics cost-effect analysis. Results in the experimental group, 13 cases were cured, 15 cases were significantly effective, the total effective rate was 87.5%, and 7 cases were cured in the control group. The clinical signs improvement time, average hospitalization time and intravenous therapy time in the experimental group were shorter than those in the control group, and the average hospitalization cost and the antimicrobial cost in the experimental group were also lower than those in the control group. Conclusion Sequential antimicrobial therapy for elderly patients with moderate and severe lower respiratory tract infection can effectively treat the disease and has good economic benefit. The best conversion time of sequential therapy is about 7 days.
【作者单位】：杭州市上城区紫阳街道社区卫生服务中心院办;
【基金】：杭州市卫生局科研基金项目(2008B0080)
【分类号】：R56

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