解整合素-金属蛋白酶33在不同严重程度哮喘患者血清中的表达水平及其与气道慢性炎症的关系

发布时间：2018-03-05 16:08

本文选题：解整合素-金属蛋白酶　切入点：哮喘严重程度　出处：《医学研究生学报》2017年05期 　论文类型：期刊论文

【摘要】：目的解整合素-金属蛋白酶33(ADAM33)是哮喘重要的易感基因之一,与哮喘发病和气道高反应性密切相关。文中评估ADAM33在不同严重程度哮喘患者血清中表达水平及其与气道慢性炎症的关系。方法回顾性分析2015年5月1日至2016年5月1日期间于南京总医院就诊的轻-中度哮喘(n=54)、重度哮喘(n=35)和对照组(n=30)患者,分别检测血清总Ig E水平、外周血嗜酸性粒细胞(EOS)计数和血清中ADAM33、IL-4和IL-13表达水平,并进行相关性分析。结果轻-中度哮喘组、重度哮喘组和对照组患者血清中ADAM33表达分别为(23.8±6.21)、(64.8±12.8)和(18.3±4.49)pg/m L,重度哮喘组和轻-中度哮喘组血清ADAM33表达均显著高于健康对照组,且重度哮喘组血清ADAM33表达也同样高于轻-中度哮喘组(P0.05)。相关分析结果显示,ADAM33表达与IL-4和IL-13呈正相关性(r=0.79、r=0.81,P0.05),而与EOS计数和血清总Ig E无相关性(r=0.54、r=0.46,P0.05)。结论 ADAM33在不同严重程度哮喘患者血清中的升高可反映哮喘的严重程度。血清IL-4和IL-13表达水平与ADAM33的正相关提示ADAM33的表达水平可能受到Th2类细胞因子的调控。
[Abstract]:Objective integrin-metalloproteinase-33 (ADAM33) is one of the important susceptibility genes to asthma. The expression of ADAM33 in serum of asthmatic patients with different severity of asthma and its relationship with chronic airway inflammation were evaluated. Methods from May 1st 2015 to 2016, we retrospectively analyzed the relationship between the expression of ADAM33 and chronic airway inflammation. From 1st to 1st, patients with mild to moderate asthma (54 cases) and severe asthma patients (35%) and control group (30 cases) with mild to moderate asthma were treated at Nanjing General Hospital in 1st. The levels of serum IgE, eosinophil eosinophils (EOS) in peripheral blood and the expression of ADAM33, IL-4 and IL-13 in serum were measured, and the correlation analysis was carried out. The expression of ADAM33 in serum of patients with severe asthma and control group was 23.8 卤6.21, 64.8 卤12.8) and 18.3 卤4.49 PG / mL, respectively. The expression of serum ADAM33 in severe asthma group and mild to moderate asthma group was significantly higher than that in healthy control group. The expression of serum ADAM33 in severe asthma group was also higher than that in mild to moderate asthma group (P 0.05). The results of correlation analysis showed that the expression of ADAM33 was positively correlated with IL-4 and IL-13, but had no correlation with EOS count and serum IgE count. Conclusion ADAM33 is of different severity. The positive correlation between the expression of IL-4 and IL-13 and ADAM33 suggests that the expression of ADAM33 may be regulated by Th2 cytokines.
【作者单位】：第二军医大学金陵医院(南京军区南京总医院)呼吸与危重症医学科;
【分类号】：R562.25

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