脉冲振荡法测定呼吸阻抗指标在支气管哮喘诊断中的应用

发布时间：2018-03-06 21:02

本文选题：脉冲振荡法　切入点：支气管哮喘　出处：《山东医药》2015年32期 　论文类型：期刊论文

【摘要】：目的探讨脉冲振荡法(IOS)测定呼吸阻抗参数在支气管哮喘诊断中的应用价值。方法对48例哮喘患者(哮喘组)和21例健康体检者(对照组)采用IOS测定呼吸阻抗指标,并行常规肺通气功能测定;比较两组呼吸阻抗指标及常规肺通气功能参数;对两组肺通气功能参数进行相关性分析;采用受试者工作特征(ROC)曲线分析IOS对支气管哮喘诊断有意义的指标。结果哮喘组IOS指标5 Hz黏性阻力(R5)、20 Hz黏性阻力(R20)、5 Hz和20 Hz黏性阻力差(R5-R20)、共振频率(Fres)、低频下电抗面积(Alx)均高于对照组(P0.05或0.01),而5 Hz频率时的周边弹性阻力(X5)低于对照组(P0.01)。相关性分析结果显示,R5、R5-R20、Fres、Alx与常规肺通气功能指标第一秒用力呼气容积占预计值的百分比、第一秒用力呼气量占用力肺活量的百分比、峰流速占预计值的百分比、最大呼气中期流速占预计值的百分比均呈负相关(P均0.01);X5与以上各指标均呈正相关(P均0.01);R20与常规肺通气功能指标无相关性(P均0.05)。ROC曲线下面积FresX5R5、AlxR5-R20R20。呼吸阻抗指标对于支气管哮喘的诊断具有较高的准确性,其中敏感度最高的参数为e Fres,特异度最高的参数为eR5-R20。结论 IOS与常规肺通气功能各指标有很好的相关性,其测定的呼吸阻抗指标诊断支气管哮喘的准确性较高。
[Abstract]:Objective to investigate the application value of respiratory impedance parameters in the diagnosis of bronchial asthma by pulse-oscillatory method. Methods Respiratory impedance indexes were measured by IOS in 48 asthmatic patients (asthma group) and 21 healthy controls (control group). The respiratory impedance index and the routine pulmonary ventilation function parameters were compared, and the correlation analysis was made between the two groups. Results in the asthmatic group, the IOS index of 5 Hz viscosity resistance is 5 Hz, the 20 Hz viscosity resistance is 5 Hz, the difference of the viscosity resistance is 5 Hz and 20 Hz, the resonance frequency is high, the frequency of resonance is Fresn, and the electric current at low frequency is obtained by using the operating characteristic of the subjects (ROC) curve to analyze the significance of IOS in the diagnosis of bronchial asthma, and the results show that the IOS index of the asthmatic group is 5 Hz, 5 Hz and 20 Hz respectively. The anti-area Alx was higher than that of the control group (P0.05 or 0.01), and the peripheral elastic resistance (X5) at 5 Hz was lower than that in the control group (P 0.01). The results of correlation analysis showed that the percentage of forced expiratory volume between R5F5-R20 FresAlx and the 1 second forced expiratory volume of routine pulmonary ventilation function index was higher than that of the control group. 1 second forced expiratory volume as a percentage of forced vital capacity, peak flow rate as a percentage of predicted value, The percentage of maximum mid-expiratory flow rate to predicted value was negatively correlated with each other (P = 0.01) and the above indexes were positively correlated (P = 0.01) and normal pulmonary ventilation function index (P = 0.05). The area under the curve of FresX5R5, AlxR5-R20R20R20. respiratory impedance index was not correlated with the conventional pulmonary ventilation function index. The diagnosis of tracheal asthma has high accuracy. Among them, the most sensitive parameter is eFresand the highest specificity is eR5-R20.Conclusion there is a good correlation between IOS and the indexes of routine pulmonary ventilation function, and the accuracy of the measured respiratory impedance index in the diagnosis of bronchial asthma is higher.
【作者单位】：北京市房山区良乡医院;首都医科大学附属北京友谊医院;
【分类号】：R562.25

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