血清c-反应蛋白、白介素-6及白介素-10水平与慢性阻塞性肺疾病的相关性研究

发布时间：2018-03-06 21:09

本文选题：C-反应蛋白　切入点：白介素-6　出处：《苏州大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：通过检测慢性阻塞性肺疾病(COPD)病人血清C-反应蛋白（CRP）、白介素-6(IL-6)和白介素-10(IL-10)的水平，，探讨其与COPD的相关性。方法：选择2013年09月～2014年02月期间在我院呼吸内科住院治疗的48例COPD急性加重期病人作为COPD急性加重期组，48例门诊随访的COPD稳定期病人作为COPD稳定期组，选择48例健康者作为健康对照组。各组研究对象的年龄、性别以及病程等因素之间比较，差异均不显著，无统计学意义（P＞0.05），具有可比性。收集与处理三组研究对象的血液标本，对各组研究对象的血清CRP、IL-6和IL-10的水平进行检测，并采用肺功能仪检测研究对象的肺功能。比较各组研究对象的血清CRP、IL-6和IL-10的水平以及肺功能，并分析血清CRP、IL-6和IL-10的水平与肺功能之间的相关性。所得数据采用SPSS13.0统计软件包进行统计分析。结果：（1）COPD急性加重期组、COPD稳定期组、健康对照组的血清CRP水平两两之间比较差异显著，具有统计学意义（P＜0.05）；COPD急性加重期组、COPD稳定期组的血清IL-6水平与健康对照组比较差异显著，具有统计学意义（P＜0.05），而COPD急性加重期组、COPD稳定期组之间差异不显著，无统计学意义（P＞0.05）；COPD急性加重期组、COPD稳定期组的血清IL-10水平与健康对照组比较差异显著，具有统计学意义（P＜0.05），而COPD急性加重期组、COPD稳定期组之间差异不显著，无统计学意义（P＞0.05）。（2）COPD急性加重期组、COPD稳定期组、健康对照组的FEV1%和FEV1/FVC两两比较差异显著，具有统计学意义（P＜0.05）。（3）COPD稳定期组与急性加重期组患者血清CRP、IL-6、IL-10水平分别与FEV1%、FEV1/FVC显著相关。结论：（1）COPD急性加重期组、COPD稳定期组、健康对照组研究对象的血清CRP、IL-6水平依次降低，而IL-10水平依次升高，它们参与了COPD疾病的炎症反应，测定血清中三者的变化对病情分析具有一定临床价值。（2）CRP、IL-6水平与FEV1%、FEV1/FVC指标负相关；IL-10水平与FEV1%、FEV1/FVC指标正相关。血清CRP、IL-6、IL-10水平可作为评估COPD病情严重程度的观察指标。
[Abstract]:Aim: to investigate the correlation between serum C-reactive protein (COPD) and interleukin-6 (IL-6) and interleukin-10IL-10 (IL-10) in patients with chronic obstructive pulmonary disease (COPD). Methods: from September 2013 to February 2014, 48 patients with acute exacerbation of COPD who were hospitalized in Department of Respiratory Medicine in our hospital were selected as COPD acute exacerbation group and 48 outpatient follow-up COPD stable patients as COPD stable group. 48 healthy subjects were selected as the healthy control group. There were no significant differences in age, sex and course of disease among the study subjects, and there was no statistical significance (P > 0.05). The blood samples of the three groups were collected and treated. The levels of serum CRPP-IL-6 and IL-10 were measured in each group, and lung function was measured by pulmonary function analyzer. The levels of serum CRPP-IL-6 and IL-10 and pulmonary function were compared. The correlation between the levels of IL-6 and IL-10 in serum and lung function was analyzed. The data were statistically analyzed by SPSS13.0 software package. Results there was a significant difference in serum CRP levels between the stable phase group and the healthy control group (P < 0.05). The serum IL-6 level in the stable phase group was significantly higher than that in the healthy control group (P < 0.05). There was no significant difference in serum IL-10 level between COPD acute exacerbation group and healthy control group (P > 0.05), but there was no significant difference between stable COPD group and COPD acute exacerbation group (P > 0.05). There was no significant difference between stable COPD group and COPD acute exacerbation group (P > 0.05). The difference between FEV1% and FEV1/FVC in healthy control group was significant. The serum levels of IL-6 and IL-10 in stable COPD group and acute exacerbation group were significantly correlated with FEV1 / FVC, respectively. Conclusion the serum levels of CRP- IL-6 in patients with acute exacerbation of IL-10 were decreased in turn, while the levels of IL-10 were increased in turn. They were involved in the inflammatory reaction of COPD disease. The determination of the three levels in serum was of certain clinical value for the analysis of the disease. The level of IL-6 was negatively correlated with the FEV1 / FVC index and the level of IL-10 was positively correlated with the FEV1 / FVC index. The level of serum CRPIL-6 / IL-10 could be used as an index to evaluate the severity of COPD.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R563.9

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