胸腰椎压缩性骨折老年患者肺部感染对CRP、IL-2和TNF-α的影响及预后分析

发布时间：2018-03-07 03:02

本文选题：胸腰椎压缩性骨折　切入点：肺部感染　出处：《中华医院感染学杂志》2016年17期 　论文类型：期刊论文

【摘要】：目的探讨胸腰椎压缩性骨折老年患者肺部感染对C-反应蛋白(CRP)、白细胞介素-2(IL-2)、肿瘤坏死因子(TNF-α)的影响及预后,为临床治疗提供参考依据。方法选择2012年1月-2015年8月100例胸腰椎压缩性骨折老年患者作为研究对象,观察肺部感染发生情况,并分析肺部感染对CRP、IL-2及TNF-α的影响,随访1年分析肺部感染对骨折预后的影响。结果老年胸腰椎压缩性骨折100例患者中,有20例发生肺部感染,感染率20.0%;感染患者CRP水平为(14.46±2.27)mg/L、IL-2水平为(3.41±0.80)pg/L、TNF-α水平为(18.48±3.45)pg/ml,均明显高于非感染患者(7.04±2.78)mg/L、(2.51±0.68)pg/L、(12.51±2.63)pg/ml,差异均有统计学意义(P0.05);随访1年感染组骨折愈合率为60.0%,明显低于非感染患者的81.3%,差异有统计学意义(P0.05)。结论肺部感染可增高胸腰椎压缩性骨折老年患者CRP、IL-2及TNF-α水平,影响胸腰段压缩性骨折老年患者的预后,临床中应引起重视。
[Abstract]:Objective to investigate the effect and prognosis of lung infection in elderly patients with thoracolumbar vertebral compression fracture on C-reactive protein (CRP), interleukin-2 (IL-2) interleukin-2 (IL-2) and tumor necrosis factor TNF- 伪 (TNF- 伪). Methods from January 2012 to August 2015, 100 elderly patients with thoracolumbar vertebral compression fracture were selected to observe the incidence of pulmonary infection, and to analyze the effect of pulmonary infection on CRP IL-2 and TNF- 伪. Results of 100 elderly patients with thoracolumbar vertebral compression fracture, 20 had pulmonary infection. The infection rate was 20.0. The level of CRP in infected patients was 14.46 卤2.27 mg / L and the level of IL-2 was 3.41 卤0.80 g / L, which was 18.48 卤3.45 mg / ml, which was significantly higher than that in non-infected patients (7.04 卤2.78 mg / L 2.51 卤0.68 mg / L = 12.51 卤2.63 mg / ml, P 0.05), and the rate of fracture healing in infected group was 60.0, which was significantly lower than that in non-infected patients (P 0.05). Conclusion Pulmonary infection can increase the levels of IL-2 and TNF- 伪 in elderly patients with thoracolumbar compression fracture. The prognosis of elderly patients with thoracolumbar compression fracture should be paid more attention in clinic.
【作者单位】：郑州人民医院骨关节外科;
【基金】：河南省科学技术基金资助项目(20139809G)
【分类号】：R687.3;R563.1

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