血清糖类抗原125水平与慢性阻塞性肺疾病患者肺动脉压力的关系

发布时间：2018-03-07 06:22

本文选题：糖类抗原　切入点：慢性阻塞性肺疾病　出处：《广东医学》2017年16期 　论文类型：期刊论文

【摘要】：目的探讨血清糖类抗原125(CA125)水平与慢性阻塞性肺疾病(COPD)患者肺动脉压力的关系,研究CA125是否在COPD合并肺动脉高压(pulmonary hypertension,PH)中具有诊断价值。方法收录稳定期COPD患者80例,其中合并PH者29例。对比有无PH患者血清CA125水平,分析CA125与心脏彩超肺动脉收缩压(systolic pulmonary artery pressure,s PAP)测定值的相关性,对CA125预测COPD患者是否合并PH绘制ROC曲线。结果合并PH患者的血清CA125水平明显高于无PH患者(Z=-3.40,P0.05),合并PH患者平均s PAP为(59.72±12.61)mm Hg,与其血清CA125水平无相关性(P0.05)。评估CA125与心脏彩超在PH诊断中的一致性,Kappa值为0.307,对CA125预测COPD是否合并PH绘制ROC曲线,得出曲线下面积(AUC)为0.723,95%可信区间为0.600~0.875,根据ROC曲线得出CA125为59.66 U/m L时,Youden指数最大为0.424,此时预测COPD患者合并PH的敏感度为48.3%,特异度为94.1%。结论 CA125测定简单易行,其水平可协助判断COPD患者是否合并PH。
[Abstract]:Objective to investigate the relationship between serum carbohydrate antigen 125 (CA125) and pulmonary artery pressure in patients with chronic obstructive pulmonary disease (COPD), and to investigate the diagnostic value of CA125 in patients with COPD complicated with pulmonary hypertension. Methods 80 patients with stable COPD were included in this study. Among them, 29 cases were complicated with PH. To compare the serum CA125 level of patients with PH or not, to analyze the correlation between CA125 and systolic pulmonary artery pressure PAPs. Results the serum CA125 level in patients with CA125 was significantly higher than that in patients without PH, and the average s PAP in patients with PH was 59.72 卤12.61 mm Hg.There was no correlation between serum CA125 level and CA125 level in patients with PH. The consistency of color Doppler ultrasound in the diagnosis of PH was 0.307, and the value of Kappa was 0.307. Whether the COPD was combined to draw the ROC curve was predicted by CA125. According to the ROC curve, the maximum value of Youden index was 0.424 when CA125 was 59.66 UmL, and the sensitivity of predicting PH in COPD patients was 48.3% and the specificity was 94.1.Conclusion CA125 is simple and feasible. Its level can help to judge whether COPD patients are associated with COPD.
【作者单位】：中国医科大学附属盛京医院呼吸内科;
【分类号】：R544.1;R563.9

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