厄他培南治疗下呼吸道感染的效果观察

发布时间：2018-03-09 01:06

本文选题：厄他培南　切入点：静脉注射　出处：《中华医院感染学杂志》2014年17期 　论文类型：期刊论文

【摘要】：目的探讨厄他培南静脉注射治疗下呼吸道细菌感染的临床效果。方法选取2011年4月-2013年4月下呼吸道感染患者90例,随机分为两组,对照组42例,观察组48例,对照组患者给予头孢哌酮/舒巴坦静脉注射,观察组患者给予厄他培南静脉注射,对两组患者治疗效果,并根据细菌培养结果对其细菌检出率和细菌清除率进行统计,记录两组患者不良反应发生率。结果观察组和对照组两组患者痊愈率分别为60.42%和54.76%,差异无统计学意义;观察组和对照组患者总有效率分别为91.67%和80.95%,观察组患者明显高于对照组,两组比较差异有统计学意义(P0.05);对照组42例患者共检出病原菌17株,检出阳性率为40.48%,清除14株,清除率为82.35%;观察组48例患者共检出病原菌20株,检出阳性率为41.67%,清除18株,清除率为90.00%;两组患者病原菌检出率和清除率差异无统计学意义;观察组患者不良反应发生率为4.17%,对照组为7.14%。结论使用厄他培南静脉注射治疗下呼吸道感染是一种安全有效的治疗方法,其效果确切、不良反应少、用药方便,可在临床推广应用。
[Abstract]:Objective to investigate the clinical effect of bacterial ertapenem intravenous injection in the treatment of lower respiratory tract infection. Methods from April 2011 -2013 years 90 patients with lower respiratory tract infection in 4, were randomly divided into two groups, 42 cases in the control group, 48 cases in the observation group, the control group were treated with cefoperazone / sulbactam intravenous injection, the patients in observation group were given intravenous ertapenem, treatment the effect of two groups of patients, and according to the results of bacterial culture of the bacteria detection rate and bacterial clearance rate statistics, the incidence of adverse reactions of two groups were recorded. Results the observation group and the control group of two groups of patients with recovery rate were 60.42% and 54.76%, there was no significant difference between groups of patients; the total effective rate was 91.67% and 80.95% observation group and control group, the patients in the observation group were significantly higher than the control group, there was significant difference between two groups (P0.05); the control group of 42 patients were detected in 17 strains of pathogenic bacteria, positive rate 40.48%, removal of 14 strains, clearance rate was 82.35%; 48 patients in the observation group, a total of 20 strains of pathogens, the positive rate was 41.67%, removal of 18 strains, clearance rate was 90%; two patients with pathogen detection rate and removal rate had no significant difference; adverse reactions of the observation group the occurrence rate was 4.17% the control group, using intravenous ertapenem was 7.14%. conclusion the treatment of lower respiratory tract infection is a safe and effective treatment method, the exact effect, less adverse reaction, convenient usage, and can be popularized in clinical application.

【作者单位】：南阳市中心医院呼吸科一病区;
【基金】：河南省卫生厅重点基金资助项目(HW-2010B101238)
【分类号】：R56

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