质子泵抑制剂与腹部外科手术患者医院获得性肺炎的相关性

发布时间：2018-03-12 09:34

本文选题：应激性溃疡出血　切入点：医院获得性肺炎　出处：《实用医学杂志》2016年07期 　论文类型：期刊论文

【摘要】：目的:探讨质子泵抑制剂(PPI)与腹部外科手术患者医院获得性肺炎(HAP)的相关性。方法:回顾性分析2010-2014年我院重症监护病房收治的腹部外科手术患者418例,按照用药分为PPI组(n=326)和HRA组(n=92),PPI组按用药分为奥美拉唑组(A组,n=146)、兰索拉唑组(B组,n=102)和潘妥拉唑组(C组,n=78),HRA组按H_2RA用药分为法莫替丁组(D组,n=58)和雷尼替丁组(E组,n=34),比较围手术期SUB发生率和HAP发生率,以及呼吸机通气时间、ICU住院时间和28 d病死率。结果:PPI组SUB发生率、HAP发生率、呼吸机通气时间、ICU住院时间和28 d病死率均低于非PPI组。PPI各亚组间SUB发生率、HAP发生率、呼吸机通气时间、ICU住院时间和28 d病死率比较差异无显著性。结论 :与使用H_2RA预防SUB比较,腹部外科手术患者使用PPI可减少SUB和HAP的发生率,缩短呼吸机通气时间和ICU住院时间,并降低28 d病死率;不同类型的PPI对腹部外科手术患者HAP发生率无影响。
[Abstract]:Objective: to investigate the correlation between proton pump inhibitor (PPI) and hospital acquired pneumonia (HAP) in patients undergoing abdominal surgery. PPI group was divided into two groups according to drug use: PPI group (n = 326) and HRA group: omeprazole group (n = 146), lansoprazole group B group (n = 102) and pantoprazole group C group (n = 8) were divided into famotidine group (D group) and ranitidine group (n = 34) according to H2RA. The incidence of SUB and HAP in perioperative period, Results the incidence rate of SUB, the duration of ventilator ventilation and the fatality rate of 28 days were lower than those of non-#en1# group. There was no significant difference between the duration of ventilator ventilation and the fatality rate of 28 days. Conclusion: compared with the prevention of SUB by H2RA, the incidence of SUB and HAP can be reduced by using PPI in patients undergoing abdominal surgery. The duration of ventilator ventilation and the hospitalization time of ICU were shortened and the fatality rate of 28 days was reduced. Different types of PPI had no effect on the incidence of HAP in patients undergoing abdominal surgery.
【作者单位】：广州市第一人民医院重症医学科;
【基金】：广州市科技攻关专项项目(编号:201300000196)
【分类号】：R656;R563.1

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