慢性阻塞性肺疾病患者使用干粉吸入器吸气能力研究

发布时间：2018-03-16 04:03

  本文选题：吸气峰流量　切入点：慢性阻塞性肺疾病　出处：《中国实用内科杂志》2014年S1期 　论文类型：期刊论文

【摘要】：目的探讨不同严重程度的慢性阻塞性肺疾病(COPD)患者在不同干粉吸入器阻力状态下的吸气能力。方法 54例中老年COPD患者纳入研究,年龄(67.7±8.4)岁,采用In-Check DIAL吸气峰流量仪,测定模拟准纳器阻力状态下的吸气峰流量(PIF-Diskus,PIF-D)以及模拟都保阻力状态下的吸气峰流量(PIF-Turbuhaler,PIF-T),同时测定呼气峰流量(PEF)以及舒张后肺功能。结果 1例(1.9%)COPD患者未能达到Diskus的最低吸气流量(30L/min)要求,12例(22.2%)未能达到Turbuhaler的最低吸气流量(60L/min)要求,两组间有统计差异(χ2=10.581,P=0.001)。对于PIF-D,7.1%的Ⅳ级COPD患者低于理想吸气流量,Ⅱ级和Ⅲ级的PIF-D均达到理想吸气流量或以上,不同级别COPD患者的PIF-D分级分布情况无统计学差异(χ2=5.665,P=0.226)。对于PIF-T,Ⅱ级、Ⅲ级、Ⅳ级的COPD患者的比例为11.8%、26.1%、28.6%,不同级别COPD患者的PIF-T分级分布情况无统计学差异(χ2=3.222,P=0.521)。经直线回归分析表明,COPD患者PEF测定值与PIF-D和PIF-T测定值均呈正相关(r值分别为0.584和0.478,P均=0.01)。结论通过COPD患者的疾病严重程度,无法判断患者是否真正有效地吸入药物。In-Check DIAL吸气峰流量仪可测定COPD患者在不同吸入器阻力状态下吸气流量,临床医生可根据患者的测定结果来为患者选用不同的吸入器,并开具合理的药物处方,适于在临床上推广应用。
[Abstract]:Objective to investigate the inspiratory capacity of patients with different severity of chronic obstructive pulmonary disease (COPD) under different resistance states of dry powder inhalers. Methods 54 middle-aged and aged COPD patients, aged 67.7 卤8.4 years, were enrolled in the study with In-Check DIAL inspiratory peak flow meter. The inspiratory peak flow (PIF-Diskusus PIF-D-) and the peak inspiratory flow (PIF-Turbuhalerus PIF-TN) were measured at the same time, and the peak expiratory flow (PEF) and the pulmonary function after diastolic were measured. Results one patient with PIF-Diskusus PIF-D- was not able to achieve Diskus. The minimum inspiratory flow (30 L / min) required 12 cases (22. 2) did not meet the minimum inspiratory flow (60 L / min) requirement of Turbuhaler. There was statistical difference between the two groups (蠂 2 + 10.581%). For grade 鈪，

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