谷胱甘肽S转移酶P1基因多态性与新疆维吾尔族慢性阻塞性肺疾病易感性的关系

发布时间：2018-03-16 05:19

本文选题：慢性阻塞性肺疾病　切入点：多态性　出处：《西安交通大学学报(医学版)》2014年04期 　论文类型：期刊论文

【摘要】：目的探讨谷胱甘肽S转移酶P1(glutathione S-transferase P1,GSTP1)基因多态性与新疆维吾尔族慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)易感性的关系。方法通过聚合酶链反应-限制性片段长度多态性(PCR-RFLP)的方法对新疆维吾尔族150例COPD患者和150例健康体检者的GSTP1基因型进行检测;利用SPSS 17软件分析该多态性位点与COPD易感性的关系,并与其他种族的基因型分布进行比较。结果在COPD组和对照组中均以AA基因型为主,两组之间的AA、AG和GG基因型分布有统计学差异(P=0.001),等位基因A和G之间亦有统计学差异(P=0.001);经调整年龄、性别和吸烟史后,分析结果表明G等位基因是COPD发病的危险因素(P=0.001,OR=2.525,95%CI=1.525~4.171)。结论在维吾尔族人群中GSTP1第5外显子105位G等位基因可能是COPD发病的危险因素。
[Abstract]:Objective to investigate the relationship between glutathione S-transferase P1S-transferase P1 (GSTP1) gene polymorphism and susceptibility to chronic obstructive pulmonary disease (Copd) in Xinjiang Uygur nationality. Methods PCR-RFLP was used to analyze the polymorphism of glutathione S-transferase S-transferase p1 gene in Xinjiang Uygur people with chronic obstructive pulmonary disease. Methods the GSTP1 genotypes of 150 COPD patients and 150 healthy controls in Xinjiang Uygur nationality were detected. The relationship between the polymorphism locus and the susceptibility to COPD was analyzed by SPSS 17 software, and compared with the genotype distribution of other races. The results showed that AA genotype was the main genotype in COPD group and control group. There were significant differences in genotype distribution of AAA AG and GG between the two groups, and there were significant differences between the alleles A and G. After adjusting for age, sex and smoking history, there was a significant difference between the two groups. The results showed that G allele was the risk factor of COPD. Conclusion the G allele at exon 5 of GSTP1 may be the risk factor of COPD in Uygur population.
【作者单位】：新疆石河子大学医学院;新疆生产建设兵团医院呼吸科;新疆维吾尔自治区人民医院呼吸二科;
【基金】：中华医学会慢性呼吸道疾病专项基金(No.07010160024)~~
【分类号】：R563.9

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