大鼠肺炎链球菌肺炎中血清铁及血红蛋白的变化

发布时间：2018-03-18 03:10

本文选题：肺炎链球菌肺炎　切入点：大鼠　出处：《中国感染与化疗杂志》2014年04期 　论文类型：期刊论文

【摘要】：目的探讨大鼠感染肺炎链球菌肺炎后血清铁及血红蛋白的变化以及感染程度与血清铁、血红蛋白之间的关系。方法将60只远交群大鼠(SD大鼠)随机分成4组,每组15只,3组为试验组,经口气管插管注入低、中、高3个梯度的菌液(通过菌量梯度反映肺炎感染严重程度),同时设1组未经口气管插管注入菌液对照组,观察第3、5、7天4组大鼠平均血清铁及血红蛋白水平,以及各试验组菌量梯度与血红蛋白及血清铁均值之间的关系。结果中、高菌量组血清铁水平第3天时与对照组相比即显著下降(P=0.009,P=0.005),低菌量组第5天时血清铁水平与对照组相比差异有统计学意义(P=0.007);中、高菌量组血红蛋白水平第5天时与对照组比较差异有统计学意义(P=0.031,P=0.046),低菌量组血红蛋白第3、5、7天与对照组相比差异均无统计学意义(P0.05),不同菌量梯度与血清铁含量平均值呈负相关(r=-0.65、r=-0.53、r=-0.61),不同菌量梯度与血红蛋白平均值之间无明确相关性。结论肺炎链球菌感染可导致大鼠血清铁及血红蛋白水平下降,感染严重程度与血清铁水平存在相关性(感染越重,血清铁水平越低),与血红蛋白水平无明确相关性。
[Abstract]:Objective to investigate the changes of serum iron and hemoglobin in rats infected with Streptococcus pneumoniae pneumonia and the relationship between the degree of infection and serum iron and hemoglobin. Methods 60 SD rats were randomly divided into 4 groups. Each group (n = 15) was treated with oral tube intubation with low, medium and high levels of bacteria solution (reflecting the severity of pneumonia infection by volume gradient), and a control group was injected with bacteria solution without oral tube intubation at the same time. To observe the average serum iron and hemoglobin levels of the 4 groups on the 7th day of the 3rd 5th day, and the relationship between the bacterial gradients and the mean values of hemoglobin and serum iron. Compared with the control group, the serum iron level of the high bacteria group decreased significantly on the third day, and the serum iron level of the low bacteria group was significantly lower than that of the control group on the 5th day. The hemoglobin level of the high bacteria group was significantly different from that of the control group on the 5th day. There was no significant difference in the hemoglobin level between the high bacteria group and the control group on the 5th day after 7 days compared with that in the control group. There was a negative correlation between serum iron and hemoglobin levels in rats caused by Streptococcus pneumoniae infection. There was a correlation between the severity of infection and serum iron level (the more severe the infection, the lower the serum iron level, the less correlated with the hemoglobin level.
【作者单位】：吉化集团公司总医院呼吸内科;吉林医药学院附属医院;
【分类号】：R563.1

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