营养支持治疗对老年肺部感染合并营养风险患者免疫功能及疗效的影响

发布时间：2018-03-18 16:23

本文选题：肠内营养支持　切入点：静脉营养支持　出处：《中国老年学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的探讨不同营养支持治疗对老年心脏病患者肺部感染合并营养风险者免疫功能及疗效的影响。方法老年肺部感染合并营养风险患者78例,随机单盲法分为A、B组各39例,A组给予肠内营养支持,B组给予混合营养支持,观察两组治疗期间营养状况〔血清白蛋白(ALB)、血清总蛋白(TP)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、血红蛋白(Hb)〕、免疫状态〔免疫球蛋白(Ig)G、IgM、IgA、T淋巴细胞CD3~+、辅助/诱导T淋巴细胞(CD4~+)、抑制/细胞毒T淋巴细胞(CD8~+)及CD4~+/CD8~+比值〕、治疗相关不良反应及并发症。所有患者随访1年,观察肺部感染复发情况。结果治疗期间两组均未见死亡患者,A组治疗后ALB、TP、Hb高于同组治疗前及B组同期(P0.05),治疗后免疫状态指标IgG、IgA、CD3~+、CD4~+、CD4~+/CD8~+高于治疗前及B组同期(P0.05),CD8~+低于治疗前及B组同期(P0.05),各项治疗相关不良反应及并发症发生率均低于B组(P0.05),随访1年,A组总有效率(4.87%)高于B组(74.36%),差异均有统计学意义(P0.05)。结论老年心血管疾病肺部感染合并营养风险患者,建议早期给予肠内营养支持,可改善患者免疫功能、营养状态,提高治疗效果。
[Abstract]:Objective to investigate the effect of nutritional support therapy on immune function and prognosis of elderly patients with pulmonary heart disease combined with nutritional risk infection. Methods 78 cases of patients with nutritional risk in old pulmonary infection, randomized single blind method divided into A, B group of 39 cases, A group received the enteral nutrition, B group received mixed nutritional support. Two groups were observed during the treatment of nutritional status, serum albumin (ALB), serum total protein (TP), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), hemoglobin (Hb), immune status, immunoglobulin (Ig) G, IgM, IgA, T lymphocytes CD3~+ helper / inducer T lymphocyte (CD4~+), suppressor / cytotoxic T lymphocytes (CD8~+) and the ratio of CD4~+/CD8~+, treatment related adverse reactions and complications. All patients were followed up for 1 years, the recurrence of observation of pulmonary infection. The two groups were no deaths results during the treatment, after treatment in group A A LB, TP, Hb higher than the same group before treatment and B group (P0.05), IgG, immune status index after treatment IgA, CD3~+, CD4~+, CD4~+/CD8~+ and B groups were higher than those before treatment (P0.05), CD8~+ and B group was lower than that before treatment (P0.05), the incidence of the treatment were lower than those in group B adverse reactions and complications (P0.05), 1 years of follow-up, the total effective rate of group A (4.87%) is higher than that of B group (74.36%), the differences were statistically significant (P0.05). Conclusion patients with nutritional risk of cardiovascular disease in the elderly pulmonary infection, suggest that early enteral nutrition support can improve the nutritional status of patients with immune function. And improve the therapeutic effect.

【作者单位】：郑州铁路职业技术学院;
【基金】：河南省科技厅科技攻关项目(No.152102310246)
【分类号】：R563.1

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