HHIP基因慢rs1828591、rs12504628与新疆维吾尔族性阻塞性肺疾病的相关性

发布时间：2018-03-19 07:15

本文选题：肺疾病　切入点：慢性阻塞性　出处：《实用医学杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的:探讨HHIP基因单核苷酸多态性与新疆维吾尔族慢性阻塞性肺疾病(COPD)易感性之间的关系。方法:以233例维吾尔族COPD患者为病例组,292例维吾尔族健康体检者为对照组,提取外周血标本DNA,运用i MLDR分型技术检测HHIP基因rs1828591、rs12504628位点多态性。结果:在对照组和COPD患者中rs1828591、rs12504628位点的基因型、等位基因频率分布及2种单体型分布无明显差异(P0.05)。rs1828591、rs12504628位点基因型与肺功能FEV1%预计值比较差异具有统计学意义(P0.05)。结论:rs1828591、rs12504628位点可能不是新疆维吾尔族COPD易感基因位点,rs1828591、rs12504628位点基因型与肺功能FEV1%预计值有关。
[Abstract]:Objective: to investigate the relationship between single nucleotide polymorphism of HHIP gene and susceptibility to chronic obstructive pulmonary disease (COPD) in Xinjiang Uygur nationality. The polymorphism of rs1828591rs12504628 in HHIP gene was detected by using I MLDR typing technique. Results: the genotype of rs1828591rs12504628 was detected in control group and COPD patients. There was no significant difference in allele frequency distribution and haplotype distribution between the genotype of rs1828591rs12504628 and the predicted value of pulmonary function FEV1.Conclusion the allele frequency distribution and the distribution of two haplotypes in Xinjiang Uygur nationality may not be the COPD susceptibility gene locus of Xinjiang Uygur nationality, rs1828591rs12504628 is different from the predicted value of pulmonary function FEV1% (P0.055.Conclusion: 1% rs1828591rs12504628 may not be a COPD susceptibility gene locus of Xinjiang Uygur nationality. Locus genotype was associated with FEV 1% predicted value of lung function.
【作者单位】：石河子大学医学院第一附属医院呼吸二科;
【基金】：国家自然科学基金项目(编号:81560009) 石河子大学医学院第一附属医院科研项目(编号:BS2016090)832008
【分类号】：R563.9

【相似文献】