特发性肺纤维化患者血清CC16和γ干扰素水平的变化及意义

发布时间：2018-03-21 12:58

本文选题：特发性肺纤维化　切入点：CC　出处：《广东医学》2016年04期 　论文类型：期刊论文

【摘要】：目的探讨特发性肺纤维化(IPF)患者血清CC16、γ干扰素(IFN-γ)水平的变化及意义。方法选取经临床确诊的IPF患者30例作为观察组,另取30例健康体检者作为对照组。用酶联免疫吸附试验法检测观察组和对照组血清CC16、IFN-γ水平,同时对观察组患者行肺功能检查。比较两组血清CC16、IFN-γ水平,观察观察组血清CC16水平与IFN-γ水平的相关性,以及血清CC16、IFN-γ水平与肺功能指标的相关性。结果观察组血清CC16水平明显低于对照组(P=0.000),血清IFN-γ水平明显高于对照组(P=0.000);观察组血清CC16水平与IFN-γ水平呈显著负相关(rs=-0.998,P=0.000),血清CC16水平与肺活量占预计值百分比(VC%pred)、一氧化碳弥散量占预计值百分比(DLCO%)均呈显著正相关(rs=0.880,P=0.000;rs=0.922,P=0.000),血清IFN-γ水平与VC%pred、DLCO%无显著相关性(rs=0.337,P=0.069;rs=0.286,P=0.125)。结论CC16可能通过调控IFN-γ参与IPF发病,检测血清CC16、IFN-γ可用于IPF的辅助诊断,且血清CC16水平可作为判断肺纤维化程度的生物标志物。
[Abstract]:Objective to investigate the changes and significance of serum CC16, IFN- 纬 levels in patients with idiopathic pulmonary fibrosis (IPF). The serum levels of CC16 IFN- 纬 in the observation group and the control group were detected by enzyme linked immunosorbent assay (Elisa), and lung function tests were performed on the patients in the observation group. The serum levels of CC16 IFN- 纬 were compared between the two groups. The correlation between serum CC16 level and IFN- 纬 level in observation group, Results the serum CC16 level was significantly lower in the observation group than that in the control group, and the serum IFN- 纬 level was significantly higher than that in the control group, while the serum CC16 level in the observation group was negatively correlated with the level of IFN- 纬, and in the observation group, there was a significant negative correlation between the serum CC16 level and the IFN- 纬 level, and there was a significant negative correlation between the serum CC16 level and the IFN- 纬 level in the observation group, and the serum IFN- 纬 level was significantly lower in the observation group than in the control group. There was a significant positive correlation between CC16 level and vital capacity as a percentage of predicted value and carbon monoxide dispersion as a percentage of predicted value. Conclusion CC16 may be involved in the pathogenesis of IPF by regulating IFN- 纬. The detection of serum CC16 and IFN- 纬 may be used in the auxiliary diagnosis of IPF, and the level of serum CC16 can be used as a biomarker to judge the degree of pulmonary fibrosis.
【作者单位】：郑州大学第二附属医院呼吸内科;
【分类号】：R563.9

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