阻塞性睡眠呼吸暂停低通气综合征患者情绪与血浆5-羟色胺水平关系研究

发布时间：2018-03-22 11:47

本文选题：睡眠呼吸暂停　切入点：阻塞性　出处：《中国全科医学》2014年33期 　论文类型：期刊论文

【摘要】：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者情绪与血浆5-羟色胺(5-HT)水平的关系。方法选取2010年6月—2013年6月河北联合大学附属医院呼吸科确诊的OSAHS患者121例为OSAHS组,另选择本院同期体检的健康人群60例为对照组,采用焦虑自评量表(SAS)判断有无焦虑,应用心境状态量表(POMS)评估情绪状态,采用酶联免疫吸附法(ELISA)测定血浆5-HT水平。结果 OSAHS组POMS评分中紧张-焦虑、忧郁-沮丧、疲惫-惰性评分高于对照组,活力-好动评分低于对照组(P0.05);OSAHS组血浆5-HT水平高于对照组(P0.05)。OSAHS程度与SAS评分呈正相关(r=0.642,P=0.000);与POMS评分中紧张-焦虑、忧郁-沮丧、疲惫-惰性评分呈正相关(r=0.515,P=0.000;r=0.526,P=0.000;r=0.318,P=0.018);与活力-好动评分呈负相关(r=-0.496,P=0.000)。OSAHS病程与SAS评分呈正相关(r=0.489,P=0.001);与POMS评分中紧张-焦虑、忧郁-沮丧、疲惫-惰性评分呈正相关(r=0.509,P=0.000;r=0.371,P=0.010;r=0.271,P=0.021);与活力-好动评分呈负相关(r=-0.474,P=0.000)。OSAHS组63例出现焦虑,发生率为52.1%;OSAHS患者焦虑组POMS评分中紧张-焦虑、忧郁-沮丧、疲惫-惰性评分高于非焦虑组,活力-好动评分低于非焦虑组(P0.05);焦虑组血浆5-HT水平高于非焦虑组(P0.05)。OSAHS患者血浆5-HT水平与SAS评分呈正相关(r=0.689,P=0.000);与POMS评分中紧张-焦虑、忧郁-沮丧评分呈正相关(r=0.522,P=0.000;r=0.548,P=0.000),与活力-好动评分呈负相关(r=-0.508,P=0.000)。结论 OSAHS患者可呈现不同的负性情绪,伴有血浆5-HT水平的升高;OSAHS患者的焦虑情绪变化与5-HT变化水平有关。
[Abstract]:Objective to investigate the effect of obstructive sleep apnea hypopnea syndrome (OSAHS) and plasma 5- in patients with emotional serotonin (5-HT) levels in patients with OSAHS. Methods from June 2010 to June 2013 the Affiliated Hospital of Hebei United University Department of respiration diagnosed 121 cases of OSAHS group, another choice of healthy people at the same period in hospital physical examination of 60 cases as control group, using the the self rating Anxiety Scale (SAS) to determine the presence of anxiety, mood state scale (POMS) assessment of emotional state, using enzyme-linked immunosorbent assay (ELISA) for determination of plasma levels of 5-HT. Results OSAHS group POMS score in tension anxiety, depressed depression, fatigue inertia score higher than the control group, restless vitality the score lower than the control group (P0.05 5-HT); the level of plasma OSAHS was higher than the control group (P0.05).OSAHS level were positively correlated with SAS score (r=0.642, P=0.000); tension and POMS score in anxiety, depression, depression, fatigue inertia score was Related (r=0.515, P=0.000; r=0.526, P=0.000; r=0.318, P=0.018); and the activity of activity score was negatively correlated (r=-0.496, P=0.000) related to the course of.OSAHS were positively correlated with SAS score (r=0.489, P=0.001); tension and POMS score in anxiety, depression, depression, fatigue inertia scores were positively related (r=0.509, P=0.000; r=0.371, P=0.010; r=0.271, P=0.021); and the activity of activity score was negatively correlated (r=-0.474, P=0.000) in 63 cases of anxiety in.OSAHS group, the incidence rate was 52.1%; OSAHS group POMS score in patients with anxiety and tension anxiety, depression, depression, fatigue inertia score higher than non anxiety group were lower than those of non - active, energetic the anxiety group (P0.05); the 5-HT level of plasma anxiety is higher than non anxiety group (P0.05) 5-HT level and plasma SAS of patients with.OSAHS score (r=0.689, P=0.000); the positive tension and POMS scores in anxiety, depression and depression scores were positively correlated (r=0.522, P=0.000; r=0.548, P=0.000), and live There was a negative correlation between the force and movement score (r=-0.508, P=0.000). Conclusion OSAHS patients can present different negative emotions, with the increase of plasma 5-HT level, and the change of anxiety in OSAHS patients is related to the level of 5-HT change.

【作者单位】：河北联合大学护理康复学院;河北联合大学附属医院;
【基金】：河北省科学技术研究与发展计划项目(09276103D-11)
【分类号】：R563.8

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