氟哌噻吨美利曲辛在难治性支气管哮喘合并负性情绪患者中的疗效研究

发布时间：2018-03-22 22:22

本文选题：氟哌噻吨美利曲辛　切入点：难治性哮喘　出处：《中国现代医学杂志》2015年25期 　论文类型：期刊论文

【摘要】：目的探讨氟哌噻吨美利曲辛在难治性支气管哮喘合并负性情绪患者中的疗效。方法选取2012年6月-2014年7月该院收治的112例合并负性情绪的难治性哮喘患者为研究对象,并随机分为观察组和对照组,两组各56例。对照组给予常规内科治疗,观察组在此基础上加用氟哌噻吨美利曲辛。比较两组治疗前后的汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、哮喘控制测试量表(ACT)评分、第1秒用力呼气容积占预计值百分比(FEV1%pre)及呼气峰流量(PEF)。结果治疗后第2和4周,观察组的HAMA和HAMD评分均显著低于对照组,ACT评分、FEV1%pre和PEF均显著高于对照组(P0.05)。结论难治性哮喘常合并焦虑、抑郁等负性情绪,在常规治疗基础上联用氟哌噻吨美利曲辛可显著改善患者的负性情绪,提高哮喘症状的控制效果,改善肺功能,值得临床推广应用。
[Abstract]:Objective to investigate the efficacy of droperazone metriaxine in the treatment of refractory bronchial asthma with negative emotion. Methods 112 patients with refractory asthma with negative emotion were selected from June 2012 to July 2014. The two groups were randomly divided into two groups: the control group and the control group, 56 cases in each group. The control group was given routine medical treatment, and the observation group was treated with droperazolidone metriaxine on this basis. The Hamilton anxiety scale (Hama) score before and after treatment was compared between the two groups. Hamilton Depression scale (Hamd) score, Asthma Control scale (ACT) score, forced expiratory volume per second (FEV1prev) and peak expiratory flow (PEFV) score were measured at 2 and 4 weeks after treatment. The scores of HAMA and HAMD in the observation group were significantly lower than those in the control group. The scores of FEV1pre and PEF were significantly higher than those in the control group (P 0.05). Conclusion the refractory asthma is often complicated with negative emotions such as anxiety and depression. On the basis of routine treatment combined with droperazothioate melitracin can significantly improve the negative mood of patients improve the control effect of asthma symptoms improve lung function and is worthy of clinical application.
【作者单位】：南方医科大学珠江医院;四川省绵阳市中心医院呼吸内科;
【分类号】：R562.25

【参考文献】