外周血白细胞CD64和CD11b指数在老年慢性阻塞性肺疾病急性期的早期诊断价值

发布时间：2018-03-28 19:34

本文选题：COPD　切入点：CD　出处：《细胞与分子免疫学杂志》2014年11期

【摘要】：目的探讨外周血白细胞CD11b指数、CD64指数在老年慢性阻塞性肺疾病(COPD)急性加重期患者的早期诊断价值。方法收集2011-03/2013-12期间九江学院附属医院入院就诊的稳定期COPD患者82例(稳定组),急性期COPD患者86例(加重组)及84例健康志愿者(对照组)。各组分别检测血常规、超敏C反应蛋白(hs-CRP),流式细胞术检测外周血白细胞CD64及CD11b的平均荧光强度(MFI),并换算成CD64指数和CD11b指数。筛选出诊断COPD急性加重期有差异的指标,绘制受试者工作特征(ROC)曲线,进行曲线下面积、临界值、灵敏度及特异性比较。结果与稳定期相比,老年COPD急性加重期CD11b指数降低和CD64指数升高,差异具有统计学意义(P0.01),但老年COPD稳定组与健康对照组差异无统计学意义(P0.05)。以CD11b指数0.94、CD64指数1.83为临界值阳性标准,其诊断COPD急性加重期的敏感度分别为62.65%和77.11%,特异性分别为79.52%和98.80%。结论外周血白细胞CD11b指数降低和CD64指数升高可作为早期诊断老年COPD急性加重的实验室依据,动态观察其水平变化,对评价治疗效果有一定价值。
[Abstract]:Objective to investigate the value of peripheral blood leukocyte CD11b index and CD64 index in the early diagnosis of elderly patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods the stable COPD patients admitted to the affiliated Hospital of Jiujiang University from 2011-03 to 2013-12 were collected. Blood routine examination was performed in 86 patients with acute COPD (plus recombination) and 84 healthy volunteers (control group). High sensitive C-reactive protein (hs-CRP), flow cytometry was used to detect the mean fluorescence intensity of CD64 and CD11b in peripheral blood leukocytes, and the CD64 index and CD11b index were converted to CD64 index and CD11b index. The differential indexes for the diagnosis of acute exacerbation of COPD were screened, and the operating characteristics of the subjects were plotted. The area, critical value, sensitivity and specificity under the marching curve line were compared. Results compared with the stable period, the CD11b index and CD64 index of the elderly patients with acute exacerbation of COPD decreased and the CD64 index increased. The difference was statistically significant (P 0.01), but there was no significant difference between the elderly COPD stable group and the healthy control group (P 0.05). The critical value of the CD11b index was 0.94and the CD64 index was 1.83. The sensitivity and specificity in diagnosing acute exacerbation of COPD were 62.65% and 77.11%, respectively. Conclusion the decrease of CD11b index of peripheral blood leukocytes and the increase of CD64 index can be used as laboratory evidence for early diagnosis of acute exacerbation of COPD in the elderly. Dynamic observation of its level is valuable to evaluate the therapeutic effect.
【作者单位】：九江学院附属医院检验科;九江学院附属医院呼吸科;
【分类号】：R563.9

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