醒脑静注射液对脑出血合并肺部感染患者神经功能与凝血功能和炎性指标的影响

发布时间：2018-03-29 19:30

本文选题：醒脑静注射液　切入点：脑出血　出处：《中华医院感染学杂志》2017年17期

【摘要】：目的观察醒脑静注射液对脑出血合并肺部感染患者神经功能、凝血功能和炎性指标的影响。方法选择2014年5月-2016年5月医院住院治疗的126例脑出血合并肺部感染患者作为研究对象,将患者随机分为对照组和观察组,每组各63例;对照组采用西医常规治疗,观察组在对照组基础上采用醒脑静注射液治疗,比较两组患者的疗效以及神经功能、凝血功能和炎性指标变化。结果观察组总有效率为81.0%,显著高于对照组的58.7%(χ~2=7.385,P=0.007);观察组治疗后NIHSS评分明显升高(P0.05),GCS评分明显下降(P0.05),与同期对照组比较差异均有统计学意义(P0.05);观察组治疗后纤维蛋白原水平明显升高(P0.05),D二聚体水平明显下降(P0.05),与同期对照组比较差异均有统计学意义(P0.05);两组治疗后IL-1β、IL-6、IL-8、IL-10和TNF-α水平均明显下降(P0.05),且观察组低于对照组水平,差异均有统计学意义(P0.05)。结论醒脑静注射液对脑出血合并肺部感染患者进行治疗,能够明显提高临床疗效,改善患者神经功能和凝血功能状态,同时抑制炎性反应,值得临床推广应用。
[Abstract]:Objective to observe the effect of Xingnaojing injection on nerve function in patients with cerebral hemorrhage complicated with pulmonary infection. Methods 126 patients with intracerebral hemorrhage complicated with pulmonary infection from May 2014 to May 2016 were randomly divided into control group and observation group with 63 cases in each group. The control group was treated with routine western medicine, the observation group was treated with Xingnaojing injection on the basis of the control group, and the curative effect and nerve function of the two groups were compared. Results the total effective rate of the observation group was 81.0, which was significantly higher than that of the control group (58.7%), and the NIHSS score of the observation group was significantly higher than that of the control group (0.007%), and the NIHSS score of the observation group was significantly higher than that of the control group (P 0.05%). After treatment, the level of fibrinogen in the observation group increased significantly and the level of P0.05 D dimer decreased significantly, which was significantly different from that in the control group, and the levels of IL-10 and TNF- 伪 in the IL-1 尾 6 IL-8 and TNF- 伪 decreased significantly after treatment, and the levels of TNF- 伪 in the observation group were lower than those in the control group. Conclusion Xingnaojing injection in treating patients with cerebral hemorrhage complicated with pulmonary infection can obviously improve the clinical efficacy, improve the neurological function and coagulation function of the patients, and inhibit inflammatory reaction. It is worth popularizing and applying in clinic.
【作者单位】：南阳市中心医院神经外科;
【分类号】：R563.1;R743.34

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