乌司他丁注射液在重症肺部感染患者中的应用研究

发布时间：2018-03-30 04:26

本文选题：乌司他丁　切入点：重症肺部感染　出处：《中华医院感染学杂志》2017年19期

【摘要】：目的探讨乌司他丁注射液治疗重症肺部感染患者的实际临床效果。方法选取2013年9月-2016年9月于医院接受治疗的86例重症肺部感染患者为研究对象,按照随机数表平均分成2组,其中43例患者接受常规治疗方案为对照组,其余43例患者在常规治疗方案基础上添加乌司他丁注射液为观察组,对患者治疗前后进行血清检测,观察患者肿瘤坏死因子(TNF-α)、C-反应蛋白(CRP)及促炎性细胞因子(IL-18)水平,采用改良患者疗效评价量表对患者的治疗效果进行评价,对两组患者治疗后出现不良反应的患者进行记录,记录患者从出现不良反应到不良反应恢复的平均时间,并且记录患者的平均住院时间。结果观察组患者显效例数共26例占60.47%,较对照组的9例占20.93%,差异有统计学意义(P0.05),而对照组无效率46.51%较观察组4.65%,差异有统计学意义(P0.05),另外观察组总有效率为93.35%,对照组53.49%;两组患者总不良反应例数对比无较大差异,观察组患者总不良反应率为41.86%,而对照组为39.53%;此外,患者出现了不良情况后,观察组患者不良情况恢复时间为(5.68±1.20)天,住院时间为(12.68±3.21)天,对照组患者恢复时间为(9.35±2.15)天,住院时间为(19.51±3.54)天,则说明患者不良情况恢复较好。结论乌司他丁注射液治疗重症肺部感染患者中有显著效果,且无发现并发症等严重病症,患者出现较少不良反应,且出现不良反应后患者恢复速度较快、住院时间较短。
[Abstract]:Objective to investigate the clinical effect of ulinastatin injection in the treatment of patients with severe pulmonary infection. Methods 86 patients with severe pulmonary infection who were treated in hospital from September 2013 to September 2016 were selected as subjects. According to the random number table, 43 patients were divided into two groups, 43 patients received routine therapy as control group, the remaining 43 patients were treated with ulinastatin injection on the basis of routine treatment regimen, and the serum levels were measured before and after treatment. The levels of TNF- 伪 TNF- 伪 C- reactive protein (CRP) and pro-inflammatory cytokine (IL-18) were observed. The therapeutic effect was evaluated by the modified patient evaluation scale. The adverse reactions of the two groups were recorded. The average time from the occurrence of adverse reactions to the recovery of adverse reactions was recorded. Results there were 26 cases of remarkable effect in the observation group (60.47 cases), which was significantly higher than that in the control group (20.93%), and the difference was statistically significant (P 0.05), while the ineffective rate in the control group (46.51%) was higher than that in the observation group (4.65%), the difference was statistically significant. In addition, the total effective rate was 93.35 in the observation group and 53.49 in the control group, and there was no significant difference in the total adverse reactions between the two groups. The total adverse reaction rate in the observation group was 41.86 and that in the control group was 39.53. In addition, the recovery time of the adverse condition was 5.68 卤1.20 days, the hospitalization time was 12.68 卤3.21 days, and the recovery time of the control group was 9.35 卤2.15 days. The duration of hospitalization was 19.51 卤3.54 days, which indicated that the adverse condition of the patients recovered better. Conclusion Ulinastatin injection has significant effect in treating patients with severe pulmonary infection, and no complications and other serious diseases are found, and the patients have fewer adverse reactions. The recovery rate of patients after adverse reactions was faster and the hospitalization time was shorter.
【作者单位】：海南西部中心医院药剂科;海南西部中心医院呼吸内科;儋州市人民医院呼吸内科;
【分类号】：R563.1

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