稳定期慢性阻塞性肺疾病患者认知功能的相关因素研究

发布时间：2018-04-02 03:14

本文选题：慢性阻塞性肺疾病　切入点：认知功能　出处：《中国现代医学杂志》2015年15期

【摘要】：目的探讨稳定期慢性阻塞性肺疾病(COPD)患者认知功能的影响因素。方法选取2013年1月-2014年11月期间该院收治的128例稳定期COPD患者为病例组,并选择同期来该院体检的75名健康成人为对照组。比较两组及病例组中各亚组的蒙特利尔认知评估量表(Mo CA)评分,通过简单线性相关和多重线性回归分析患者的Mo CA评分与各因素的关系。结果病例组的Mo CA评分显著低于对照组(P0.05)。年龄、吸烟指数、受教育时间、COPD严重程度、病程、Pa O2、Pa CO2、SO2、SAS及SDS评分的各亚组的Mo CA评分比较,差异有统计学意义(P0.05)。Mo CA评分与Pa O2、SO2成正相关,与年龄、COPD严重程度、SDS评分负相关(P0.05)。结论稳定期COPD患者存在不同程度的认知功能障碍,高龄、肺功能显著降低、低氧血症、抑郁表现是患者发生认知功能障碍的高危因素,应进行早期诊治。
[Abstract]:Objective to investigate the influencing factors of cognitive function in patients with stable chronic obstructive pulmonary disease (cod). Methods 128 patients with stable COPD from January 2013 to November 2014 were selected as the case group. 75 healthy adults in the same period were selected as control group. The scores of Montreal Cognitive Assessment scale (MCAS) were compared between the two groups and each subgroup of the case group. By simple linear correlation and multiple linear regression analysis, the relationship between the scores of Mo CA and various factors was analyzed. Results the scores of Mo CA in the case group were significantly lower than those in the control group (P 0.05). Age, smoking index, time of education were significantly lower than those of the control group. There was a positive correlation between the scores of Mo CA and PAO _ 2 O _ 2 so _ 2 in different subgroups of PAO _ 2 / CO _ 2O _ 2SO _ 2 and SDS scores. There was a positive correlation between the scores of Mo CA and so _ 2 of Pao _ 2O _ 2, the difference was significant (P < 0.05). Conclusion the patients with COPD at stable stage have different degree of cognitive dysfunction, the elderly, the decrease of pulmonary function, hypoxemia and depression are the high risk factors of cognitive dysfunction. Early diagnosis and treatment should be carried out.
【作者单位】：峨眉山市人民医院;
【分类号】：R563.9

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