ω-3鱼油脂肪乳对AECOPD行机械通气患者氧化应激及炎症反应的影响

发布时间：2018-04-05 07:42

本文选题：肺疾病　切入点：慢性阻塞性　出处：《山东医药》2015年40期

【摘要】：目的探讨ω-3鱼油脂肪乳对慢性阻塞性肺疾病急性加重(AECOPD)行机械通气患者氧化应激及炎症反应的影响。方法将92例AECOPD患者随机分为观察组47例和对照组45例。两组均予常规治疗、营养支持及机械通气治疗。在此基础上,对照组给予20%中长链脂肪乳剂、观察组给予10%ω-3鱼油脂肪乳静脉持续输注,均治疗1周。两组分别于治疗前(T0)及治疗3(T1)、7天(T2)检测外周静脉血及支气管肺泡灌洗液超氧化物歧化酶(SOD)、丙二醛(MDA)、CRP、IL-1β、IL-6及TNF-α水平。结果与T0时比较,观察组T2时血清及支气管肺泡灌洗液中SOD水平升高,MDA、CRP、IL-1β、IL-6和TNF-α水平均降低(P均0.05);且观察组T2时血清及支气管肺泡灌洗液中SOD水平高于对照组,MDA、CRP、IL-1β、IL-6和TNF-α水平均低于对照组(P均0.05)。而T1时两组多数指标变化不明显。结论ω-3鱼油脂肪乳可减轻行机械通气的AECOPD患者氧化应激及炎症反应,有助于改善其预后。
[Abstract]:Objective to investigate the effects of 蠅 -3 fish oil fat emulsion on oxidative stress and inflammatory response in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).Methods 92 patients with AECOPD were randomly divided into observation group (n = 47) and control group (n = 45).Both groups were treated with routine treatment, nutritional support and mechanical ventilation.On this basis, the control group was given 20% medium-long chain fat emulsion, and the observation group was given 10% 蠅 -3 fish oil fat emulsion for 1 week.The levels of superoxide dismutase (SOD) in peripheral venous blood and bronchoalveolar lavage fluid (BALF), malondialdehyde (MDA) and the levels of IL-1 尾, IL-6 and TNF- 伪 in peripheral venous blood and bronchoalveolar lavage fluid were measured before and after treatment.Results compared with T0,At T 1, most of the indexes in the two groups did not change significantly.Conclusion 蠅 -3 fish oil fat emulsion can alleviate oxidative stress and inflammatory reaction in patients with AECOPD undergoing mechanical ventilation, and can improve its prognosis.
【作者单位】：阜阳市人民医院;
【分类号】：R563.9

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