住院AECOPD患者临床特点及其与季节性变化的气象因素的相关性研究

发布时间：2018-04-05 14:38

本文选题：肺疾病　切入点：慢性阻塞性　出处：《中国全科医学》2017年24期

【摘要】：目的探讨住院慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床特点及其与季节性变化的气象因素的关系。为临床上探索预防AECOPD反复发作的措施及进行有针对性的宣教提供指导。方法回顾2010年1月—2013年6月在首都医科大学附属北京世纪坛医院住院的AECOPD患者921例,其中符合纳入标准的736例。同期北京当地气象因素资料来自中国气象科学数据共享服务网中的中国地面国际交互站气候资料月数据集,包括温差、气温、气压、湿度、风速、日照时间,其与气象因素的相关性采用直线相关分析。结果 736例住院AECOPD患者,病情分组以D组为主(597例,81.1%);痰培养阳性225例(30.6%),其中细菌培养阳性188例,真菌培养阳性82例,两者均阳性45例。共检出病原菌651株,其中细菌549株(84.3%)(革兰阴性菌483株,革兰阳性菌66株),真菌102株(15.7%)。细菌培养阳性率与温差、气压呈负相关(r=-0.662,P=0.019;r=-0.596,P=0.041),与湿度呈正相关(r=0.600,P=0.039)。糖皮质激素应用率与日照时间呈负相关(r=-0.687,P=0.014)。结论住院AECOPD患者的某些临床特点与季节性变化的温差、气压、湿度及日照时间存在相关性。
[Abstract]:Objective to investigate the clinical characteristics of AECOPD patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and its relationship with seasonal meteorological factors.To explore the clinical measures to prevent the recurrence of AECOPD and to provide guidance for targeted education.Methods from January 2010 to June 2013, 921 AECOPD patients were hospitalized in Beijing Century altar Hospital affiliated to Capital Medical University, including 736 patients who met the inclusion criteria.During the same period, local meteorological factors in Beijing were collected from the monthly climate data set of China Terrestrial International Interactive Station in China Meteorological Science data sharing Service Network, including temperature difference, temperature, air pressure, humidity, wind speed, sunshine time,Linear correlation analysis was used to analyze its correlation with meteorological factors.Results among the 736 hospitalized AECOPD patients, 597 cases were divided into group D and group D, and 225 cases were positive for sputum culture, in which 188 cases were positive for bacterial culture and 82 cases were positive for fungal culture, both of which were positive in 45 cases.A total of 651 strains of pathogenic bacteria were detected, of which 549 strains (483 Gram-negative bacteria, 66 Gram-positive bacteria and 102 fungi) were identified.The positive rate of bacterial culture was negatively correlated with temperature and air pressure. The positive rate of bacterial culture was negatively correlated with the temperature and the air pressure. The positive rate of bacteria culture was negatively correlated with the temperature, and the positive rate was negatively correlated with the temperature, and the air pressure was negatively correlated with the humidity.There was a negative correlation between glucocorticoid application rate and sunshine time.Conclusion some clinical features of inpatients with AECOPD are correlated with seasonal variation of temperature, air pressure, humidity and sunshine time.
【作者单位】：首都医科大学附属北京世纪坛医院呼吸与危重症医学科;北京朝阳医院呼吸与危重症医学科;北京大学国际医院呼吸内科;中国人民解放军总医院健康管理研究所;
【分类号】：R563.9

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