矿区成人社区获得性肺炎非典型病原体分布调查

发布时间：2018-04-10 12:56

本文选题：成人 + 社区获得性肺炎　；参考：《中华医院感染学杂志》2014年15期

【摘要】：目的了解煤矿矿区成人社区获得性肺炎(CAP)非典型病原体分布及影响因素,为初始抗感染经验治疗提供参考依据。方法采用多中心调查的方法,收集2011年10月-2012年9月煤矿矿区4所医院呼吸内科102例确诊为CAP成人住院患者的临床资料,并采集急性期和间隔2~4周恢复期患者的静脉血进行非典型病原体抗体检测,应用SPSS13.0进行分析。结果 102例CAP患者检出非典型病原体18株,阳性率为17.7%,其中肺炎支原体16株占15.7%,肺炎衣原体2株占2.0%;非典型病原体在18~49岁患者中的检出率高于≥50岁患者;非典型病原体在未合并其他疾病和肺炎严重指数(PORT)Ⅰ级更常见,差异有统计学意义(P0.05)。结论煤矿矿区成人CAP患者的非典型病原体以肺炎支原体为主;对18~49岁年龄段、无基础疾病、PORTⅠ级轻症CAP患者经验性抗感染治疗应涵盖非典型病原体。
[Abstract]:Objective to investigate the distribution and influencing factors of atypical pathogens of adult community acquired pneumonia (CAP) in coal mining area, and to provide reference for initial anti-infection experience therapy.Methods the clinical data of 102 adult inpatients with CAP in respiratory department of 4 coal mine hospitals from October 2011 to September 2012 were collected by multi-center investigation.Venous blood samples were collected from patients in acute stage and convalescent stage at intervals of 2 weeks to detect antibodies against atypical pathogens. SPSS13.0 was used to analyze them.Results 18 strains of atypical pathogens were detected in 102 patients with CAP, the positive rate was 17.7%, including 16 strains of mycoplasma pneumoniae and 2.0 strains of chlamydia pneumoniae, the detection rate of atypical pathogens in 1849 years old patients was higher than that in patients over 50 years old.Atypical pathogens were more common in PORTI without other diseases and pneumonia, and the difference was statistically significant (P 0.05).Conclusion Mycoplasma pneumoniae is the main atypical pathogen in adult CAP patients in coal mining area, and the empirical anti-infection therapy should cover atypical pathogens in patients with CAP with mild CAP without basic disease in the age group of 49 years.
【作者单位】：河北联合大学附属开滦总医院呼吸内科;河北联合大学附属开滦总医院感染管理科;开滦总医院范各庄医院儿科;
【基金】：中国煤炭工业协会科学技术研究指导性计划基金项目(MTKJ2011-459)
【分类号】：R563.1

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