E-钙粘蛋白异常表达与支气管哮喘研究进展

发布时间：2018-04-15 15:09

本文选题：E-钙粘蛋白 + 支气管哮喘　；参考：《中国药理学通报》2015年10期

【摘要】：支气管哮喘是一种严重影响人们生活质量的呼吸系统疾病,多种因素介导该病的发生与发展,其中尤以E-钙粘蛋白(E-cadherin,E-cad)的异常表达最为关键。研究发现,Ecad是一种重要的细胞黏附分子,其主要功能在于维持细胞之间的结构完整性以及参与改善气道的重塑和免疫功能的修复。进一步研究表明,支气管哮喘患者的气道上皮细胞其粘膜屏障功能常常遭受破坏,且黏膜分子E-cad的表达明显降低,这表明E-cad的异常表达参与了支气管哮喘的发生。该文对近年来E-cad的异常表达与支气管哮喘研究进展进行综述,重点对E-cad异常表达介导支气管哮喘发生发展的分子机制进行概述,并对靶向E-cad治疗支气管哮喘的策略进行探讨,为临床的后续研究和治疗提供参考。
[Abstract]:Bronchial asthma is a serious impact on the quality of people's lives, respiratory system disease, many factors mediate the occurrence and development of the disease, especially E- cadherin (E-cadherin, E-cad) expression is the key. The study found that Ecad is an important cell adhesion molecule, its main function is to maintain the integrity of the structure between the cells and improve the immune function and participate in the repair of airway remodeling. Further study showed that patients with bronchial asthma airway epithelial cells in the mucosal barrier function is often destroyed, and mucosal molecular E-cad expression was significantly decreased, suggesting that the abnormal expression of E-cad is involved in the pathogenesis of bronchial asthma. Research Progress on abnormal expression in recent years the E-cad and the bronchial asthma is reviewed in this paper, focusing on the molecular mechanism of the abnormal expression of E-cad mediated bronchial asthma development are summarized, and the target The strategy of E-cad for the treatment of bronchial asthma is discussed in order to provide reference for clinical follow-up study and treatment.

【作者单位】：南京中医药大学药学院;江苏省中药药效与安全性评价重点实验室;南京中医药大学附属苏州市中医医院苏州市吴门医派研究院;
【基金】：国家自然科学基金资助项目(No 81473395,81373549,81073121) 江苏省自然科学基金项目资助(No BK20141466) 江苏高校优势学科建设工程资助项目江苏省儿童呼吸疾病(中医药)重点实验室资助项目(JKLPRD201405)
【分类号】：R562.25

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