纤维支气管镜肺灌洗对ICU机械通气合并肺部感染患者降钙素原和C反应蛋白的影响研究

发布时间：2018-04-16 01:19

本文选题：支气管镜 + 肺疾病　；参考：《中国全科医学》2015年03期

【摘要】：目的探讨纤维支气管镜肺灌洗对ICU机械通气合并肺部感染患者血清降钙素原(PCT)以及C反应蛋白(CRP)的影响。方法采用目的抽样法选取2013年1月—2014年1月于江苏大学附属宜兴市人民医院ICU住院的机械通气合并肺部感染患者88例为研究对象,按其入ICU顺序及病种特点等分为纤维支气管镜肺灌洗组(观察组)及常规吸痰组(对照组),各44例,检测治疗前及治疗7 d时观察组和对照组患者PCT、CRP水平,比较两组治疗效果。结果观察组有效率为93.2%(41/44),对照组有效率为81.8%(36/44),差异有统计学意义(χ2=8.641,P0.05)。观察组治疗7 d时感染程度与对照组比较,差异有统计学意义(Z=-2.879,P0.05)。观察组治疗7 d时CRP水平低于对照组(t=-48.792,P0.05)。观察组及对照组治疗7 d时CRP水平均低于治疗前(t=27.839、24.049,P0.05)。结论 ICU机械通气合并肺部感染患者行纤维支气管镜肺灌洗可有效降低其PCT、CRP水平,对控制肺部感染起积极作用。
[Abstract]:Objective to investigate the effect of bronchofiberscope lung lavage on serum procalcitonin (procalcitonin) and C-reactive protein (CRP) in patients with ICU mechanical ventilation complicated with pulmonary infection.Methods from January 2013 to January 2014, 88 patients with mechanical ventilation complicated with pulmonary infection in ICU affiliated to Yixing City people's Hospital of Jiangsu University were selected by objective sampling method.According to the sequence of ICU entry and the characteristics of the disease, the patients were divided into two groups: lung lavage group (observation group) and routine sputum aspiration group (control group, 44 cases). The levels of ICU in observation group and control group were measured before treatment and 7 days after treatment, and the therapeutic effects were compared between the two groups.Results the effective rate of the observation group was 93.2g / 44 and that of the control group was 81.8 / 44.The difference was statistically significant (蠂 ~ 2 = 8.641 / P 0.05).Compared with the control group, the infection degree of the observation group was significantly different from that of the control group on the 7th day after treatment.The level of CRP in the observation group was lower than that in the control group at 7 days after treatment.The level of CRP in the observation group and the control group was lower than that in the control group after 7 days treatment.Conclusion Pulmonary lavage with fiberoptic bronchoscopy can effectively reduce the level of ICU in patients with pulmonary infection and play an active role in controlling pulmonary infection.
【作者单位】：江苏大学临床医学院;江苏大学附属宜兴市人民医院EICU;
【分类号】：R563

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