肺康复对老年慢性阻塞性肺疾病稳定期患者血清炎症因子的影响

发布时间：2018-04-17 06:57

本文选题：慢性阻塞性肺疾病 + 肺康复　；参考：《中国康复医学杂志》2016年04期

【摘要】：目的:研究肺康复对老年慢性阻塞性肺疾病(COPD)稳定期患者临床症状改善与血清炎症因子的变化。方法:前瞻性地收集老年COPD稳定期患者,分为肺康复组和对照组,肺康复组进行12周的肺康复训练,对照组采用常规内科用药,2组分别于治疗前后测定肺功能、6分钟步行试验(6MWT)、COPD患者自我评估测试(CAT)以及血清C-反应蛋白(CRP),纤维蛋白原(Fbg),白细胞介素-6(IL-6)和肿瘤坏死因子(TNF-ɑ)水平,并进行组内比较。结果:共纳入老年COPD患者51例,分为2组,肺康复组26例,对照组25例。治疗12周后,与治疗前比较,肺康复组患者的6MWT增加、CAT降低(P0.05),肺功能的FEV1%、FEV1/FVC较治疗前明显增加(P0.01);治疗后肺康复组的血清CRP、TNF-ɑ水平均比治疗前下降(P0.05),而肺康复组的IL-6、Fbg无明显变化(P0.05)。对照组治疗前后肺功能、6MWT、CAT及血炎症因子均有变化,但无显著性差异(P0.05)。结论:老年COPD稳定期患者通过肺康复治疗可以缓解呼吸困难症状,提高活动能力和耐力,延缓肺功能损害的进展;也可以降低部分血炎症因子的水平,有利于延缓COPD的进展。
[Abstract]:Aim: to study the effects of pulmonary rehabilitation on the clinical symptoms and serum inflammatory factors in elderly patients with chronic obstructive pulmonary disease (COPD) at stable stage.Methods: elderly patients with stable COPD were prospectively collected and divided into two groups: lung rehabilitation group and control group. The lung rehabilitation group received 12 weeks of lung rehabilitation training.The patients in the control group were treated with routine internal medicine. The levels of CAT, serum C-reactive protein (CRP), fibrinogen (FbgG), interleukin-6 (IL-6) and tumor necrosis factor (TNF-) were measured before and after treatment.The intragroup comparison was carried out.Results: 51 elderly patients with COPD were divided into two groups: lung rehabilitation group (n = 26) and control group (n = 25).After 12 weeks of treatment, compared with before treatment, the level of 6MWT increased and cat decreased (P 0.05), and the FEV1 / FVC of pulmonary function increased significantly (P 0.01) in the lung rehabilitation group, and the serum level of CRP / TNF-N in the lung rehabilitation group was lower than that before treatment (P 0.05), but the level of IL-6 FBG in the lung rehabilitation group was not changed significantly (P 0.05).In the control group, the changes of cat and serum inflammatory factors were observed before and after treatment, but there was no significant difference between the two groups (P 0.05).Conclusion: lung rehabilitation therapy can relieve dyspnea, improve activity and endurance, delay the progression of pulmonary function damage, and decrease the level of some blood inflammatory factors, which is helpful to delay the progress of COPD.
【作者单位】：辽宁医学院航天中心医院研究生培养基地;北京市中关村医院;
【基金】：北京市海淀区科技项目(K2012011S)
【分类号】：R563.9

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