急性脑梗死患者肺部感染病原菌分布及对氧化应激反应蛋白的影响研究

发布时间：2018-04-18 09:48

本文选题：急性脑梗死 + 肺部感染　；参考：《中华医院感染学杂志》2015年20期

【摘要】：目的研究急性脑梗死发生肺部感染患者病原菌分布及对氧化应激反应蛋白表达的影响,为临床治疗提供参考依据。方法对2011年4月-2014年4月医院诊治的110例急性脑梗死患者肺部感染病原菌进行分离、培养和鉴定,检测患者血清中丙二醛(MDA)、超氧化物歧化酶(SOD)、过氧化氢酯(CAT)和谷胱甘肽过氧化物酶(GSHpx)水平,ELISA法分析血清中NADPH氧化酶亚基的表达。结果 110例急性脑梗死发生肺部感染患者共分离出病原菌396株,其中革兰阳性菌占55.05%,革兰阴性菌占44.95%;患者血清中MDA及p22、p47、p67亚基和gp91亚基表达明显升高,而SOD、CAT和GSHpx水平明显降低。结论急性脑梗死发生肺部感染患者病原菌中,革兰阳性菌和革兰阴性菌比例相当,且感染能诱导患者氧化应激蛋白水平升高。
[Abstract]:Objective to study the distribution of pathogenic bacteria and its effect on the expression of oxidative stress protein in patients with pulmonary infection after acute cerebral infarction.Methods the pathogenic bacteria of pulmonary infection in 110 patients with acute cerebral infarction from April 2011 to April 2014 were isolated, cultured and identified.The levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (cat) and glutathione peroxidase (GSHpx) in serum were determined. The expression of NADPH oxidase subunits in serum was analyzed by Elisa.Results A total of 396 strains of pathogenic bacteria were isolated from 110 patients with pulmonary infection of acute cerebral infarction, among which Gram-positive bacteria accounted for 55.05 and Gram-negative bacteria accounted for 44.95.The expression of MDA, p22, p47, p67 subunit and gp91 subunit in serum increased significantly, while the levels of SODD-cat and GSHpx decreased significantly.Conclusion the proportion of Gram-positive bacteria and Gram-negative bacteria in patients with pulmonary infection caused by acute cerebral infarction is the same, and the level of oxidative stress protein can be increased by infection.
【作者单位】：安顺市人民医院神经内科;贵州省人民医院神经内科;
【基金】：贵州省科技计划基金资助项目(201404)
【分类号】：R743.33;R563.1

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